Detailed information of TA system TA078909

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-ArgA
• Location: 4743898..4744717
• Replicon: chromosome
• Accession: NZ_CP022348
• Organism: Klebsiella michiganensis strain K516

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: CF000_RS23075
• Protein ID: WP_004110819.1
• Coordinates: 4743898..4744155 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: CF000_RS23080
• Protein ID: WP_014837489.1
• Coordinates: 4744166..4744717 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CF000_RS23060	4739574..4740350	-	777	WP_004847986.1	Uxu operon transcriptional regulator	-
CF000_RS23065	4740489..4741964	-	1476	WP_014228053.1	fructuronate reductase	-
CF000_RS23070	4742038..4743222	-	1185	WP_014228054.1	mannonate dehydratase	-
CF000_RS23075	4743898..4744155	+	258	WP_004110819.1	YjhX family toxin	Toxin
CF000_RS23080	4744166..4744717	+	552	WP_014837489.1	N-acetyltransferase	Antitoxin
CF000_RS23085	4744735..4746363	+	1629	WP_014837490.1	SAM-dependent methyltransferase	-
CF000_RS32195	4746397..4746555	+	159	Protein_4392	hypothetical protein	-
CF000_RS23090	4746552..4746967	+	416	Protein_4393	type II toxin-antitoxin system VapC family toxin	-
CF000_RS23095	4747236..4747709	-	474	WP_032693194.1	hypothetical protein	-
CF000_RS23100	4748020..4748793	-	774	WP_088168442.1	Zygote formation protein zyg1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (22-130)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T78909 WP_004110819.1 NZ_CP022348:4743898-4744155 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T78909 NZ_CP022348:4743898-4744155 [Klebsiella michiganensis]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACATCCGCGATGCATC
AGGCCGCGTCACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCTTACCGCATCAATACCACCGGGCTGAATAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19902.64 Da
• Isoelectric Point: 6.4913

>AT78909 WP_014837489.1 NZ_CP022348:4744166-4744717 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGELIRHGIEQLKAMGSQAVFVLGHAAYYPRHGFEPGAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT78909 NZ_CP022348:4744166-4744717 [Klebsiella michiganensis]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCGACGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGCTATCGCTGCTGGCCA
GGCATAACGGAGAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGAGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCAATGGGAAGCCAGGCGGTATTTGTTCTGGGCCACGCCGCTTACTACCCCAGGCACGGGTTTGAGCCAGGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGCGGCGCATAAAGCCTGCTGGATGCTGCAGCCGATTTCGTCT
CAGCCGCTGGGACGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2