Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-ArgA
Location 4743898..4744717 Replicon chromosome
Accession NZ_CP022348
Organism Klebsiella michiganensis strain K516

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag CF000_RS23075 Protein ID WP_004110819.1
Coordinates 4743898..4744155 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag CF000_RS23080 Protein ID WP_014837489.1
Coordinates 4744166..4744717 (+) Length 184 a.a.

Genomic Context

CF000_RS23075CF000_RS23080CF000_RS23085CF000_RS32195CF000_RS23090CF000_RS23060CF000_RS23065CF000_RS23070CF000_RS23095CF000_RS23100
Location: 4743898..4744155 (258 bp)
Type: Toxin
Protein ID: WP_004110819.1
Location: 4744166..4744717 (552 bp)
Type: Antitoxin
Protein ID: WP_014837489.1
Location: 4744735..4746363 (1629 bp)
Type: Others
Protein ID: WP_014837490.1
Location: 4746397..4746555 (159 bp)
Type: Others
Protein ID: Protein_4392
Location: 4746552..4746967 (416 bp)
Type: Others
Protein ID: Protein_4393
Location: 4739574..4740350 (777 bp)
Type: Others
Protein ID: WP_004847986.1
Location: 4740489..4741964 (1476 bp)
Type: Others
Protein ID: WP_014228053.1
Location: 4742038..4743222 (1185 bp)
Type: Others
Protein ID: WP_014228054.1
Location: 4747236..4747709 (474 bp)
Type: Others
Protein ID: WP_032693194.1
Location: 4748020..4748793 (774 bp)
Type: Others
Protein ID: WP_088168442.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CF000_RS230604739574..4740350-777WP_004847986.1Uxu operon transcriptional regulator-
CF000_RS230654740489..4741964-1476WP_014228053.1fructuronate reductase-
CF000_RS230704742038..4743222-1185WP_014228054.1mannonate dehydratase-
CF000_RS230754743898..4744155+258WP_004110819.1YjhX family toxinToxin
CF000_RS230804744166..4744717+552WP_014837489.1N-acetyltransferaseAntitoxin
CF000_RS230854744735..4746363+1629WP_014837490.1SAM-dependent methyltransferase-
CF000_RS321954746397..4746555+159Protein_4392hypothetical protein-
CF000_RS230904746552..4746967+416Protein_4393type II toxin-antitoxin system VapC family toxin-
CF000_RS230954747236..4747709-474WP_032693194.1hypothetical protein-
CF000_RS231004748020..4748793-774WP_088168442.1Zygote formation protein zyg1-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(22-130)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T78909 WP_004110819.1 NZ_CP022348:4743898-4744155 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

>T78909 NZ_CP022348:4743898-4744155 [Klebsiella michiganensis]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACATCCGCGATGCATC
AGGCCGCGTCACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCTTACCGCATCAATACCACCGGGCTGAATAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 19902.64 Da        Isoelectric Point: 6.4913

>AT78909 WP_014837489.1 NZ_CP022348:4744166-4744717 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGELIRHGIEQLKAMGSQAVFVLGHAAYYPRHGFEPGAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp

>AT78909 NZ_CP022348:4744166-4744717 [Klebsiella michiganensis]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCGACGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGCTATCGCTGCTGGCCA
GGCATAACGGAGAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGAGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCAATGGGAAGCCAGGCGGTATTTGTTCTGGGCCACGCCGCTTACTACCCCAGGCACGGGTTTGAGCCAGGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGCGGCGCATAAAGCCTGCTGGATGCTGCAGCCGATTTCGTCT
CAGCCGCTGGGACGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3H6Y2

Antitoxin

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Source
ID
Structure
No matching records found

References