Detailed information of TA system TA078891

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2652740..2653230
• Replicon: chromosome
• Accession: NZ_CP022340
• Organism: Enterococcus mundtii strain EMB156

Toxin (Protein)

• Gene name: relE
• Uniprot ID: V5XU14
• Locus tag: CO646_RS12650
• Protein ID: WP_010734226.1
• Coordinates: 2652740..2653012 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V5XRI7
• Locus tag: CO646_RS12655
• Protein ID: WP_010734225.1
• Coordinates: 2653009..2653230 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CO646_RS12630	2648151..2649917	-	1767	WP_010734229.1	aspartate--tRNA ligase	-
CO646_RS12635	2649917..2651224	-	1308	WP_010734228.1	histidine--tRNA ligase	-
CO646_RS12645	2651632..2652582	+	951	WP_096081804.1	aldo/keto reductase	-
CO646_RS12650	2652740..2653012	-	273	WP_010734226.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CO646_RS12655	2653009..2653230	-	222	WP_010734225.1	hypothetical protein	Antitoxin
CO646_RS12660	2653323..2654582	-	1260	WP_010734224.1	cytochrome P450	-
CO646_RS12670	2655162..2655608	-	447	WP_010734223.1	D-tyrosyl-tRNA(Tyr) deacylase	-
CO646_RS12675	2655620..2657833	-	2214	WP_010734222.1	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-89)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10642.34 Da
• Isoelectric Point: 10.3153

>T78891 WP_010734226.1 NZ_CP022340:c2653012-2652740 [Enterococcus mundtii]
MRKQYLVRYEKGAQKALKKMDKFQASLILSWIEKNLINTDNPRQYGKGLVANRSGEWRYRVGNYRIIADIDDEVITILIV
QIGHRNDIYK

Nucleotide

• Length: 273 bp

>T78891 NZ_CP022340:c2653012-2652740 [Enterococcus mundtii]
ATGAGGAAGCAATATCTTGTCCGTTATGAAAAAGGTGCACAAAAAGCATTGAAAAAAATGGATAAATTTCAAGCTTCTTT
GATACTATCATGGATAGAAAAAAATCTTATCAATACAGATAACCCCAGACAATATGGTAAAGGGTTAGTAGCGAATAGGA
GTGGCGAATGGCGTTATAGAGTGGGGAATTATCGGATCATTGCAGATATAGATGATGAAGTGATAACGATTTTGATCGTA
CAAATTGGTCATCGAAATGACATCTATAAATAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8382.54 Da
• Isoelectric Point: 4.2571

>AT78891 WP_010734225.1 NZ_CP022340:c2653230-2653009 [Enterococcus mundtii]
MSNITFRVSDEEKAFMLAMADLNGMTVSELARTTLLETLEDQIDMDIYNKAMKDHKSLDESISHEEMKRELGL

Nucleotide

• Length: 222 bp

>AT78891 NZ_CP022340:c2653230-2653009 [Enterococcus mundtii]
ATGAGTAATATTACGTTTCGTGTATCAGACGAAGAAAAAGCATTTATGTTAGCAATGGCTGATTTGAATGGAATGACCGT
TTCAGAATTGGCAAGGACAACTTTATTAGAAACGCTAGAAGATCAGATTGATATGGATATCTATAATAAAGCGATGAAAG
ATCATAAGAGTCTTGATGAAAGTATCTCGCATGAAGAAATGAAAAGAGAACTAGGATTATGA

Structures

Toxin

• AlphaFold DB: V5XU14

Antitoxin

• AlphaFold DB: V5XRI7