Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2386058..2386629 Replicon chromosome
Accession NZ_CP022340
Organism Enterococcus mundtii strain EMB156

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CO646_RS11435 Protein ID WP_096081740.1
Coordinates 2386058..2386399 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CO646_RS11440 Protein ID WP_096081741.1
Coordinates 2386399..2386629 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO646_RS11410 2381258..2381641 - 384 WP_010734620.1 phage holin family protein -
CO646_RS11415 2381652..2382335 - 684 WP_010734619.1 LysM peptidoglycan-binding domain-containing protein -
CO646_RS11420 2382494..2382994 - 501 WP_023520261.1 hypothetical protein -
CO646_RS11425 2383117..2384391 - 1275 WP_096081738.1 hypothetical protein -
CO646_RS11430 2384635..2385543 + 909 WP_096081739.1 IS982 family transposase -
CO646_RS11435 2386058..2386399 - 342 WP_096081740.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CO646_RS11440 2386399..2386629 - 231 WP_096081741.1 AbrB family transcriptional regulator Antitoxin
CO646_RS11445 2386870..2387445 + 576 WP_023520684.1 recombinase family protein -
CO646_RS11455 2387958..2390651 - 2694 WP_096081743.1 BspA family leucine-rich repeat surface protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 2384635..2387445 2810


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13173.33 Da        Isoelectric Point: 9.3979

>T78889 WP_096081740.1 NZ_CP022340:c2386399-2386058 [Enterococcus mundtii]
VSEDKNYIPKKGDIVWIDFDPLTGNEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNLPTRYSLPEDLDTNGQVLISQ
LKSLDFKERKLKKIENLPLQDMAKIDQVIQYIF

Download         Length: 342 bp

>T78889 NZ_CP022340:c2386399-2386058 [Enterococcus mundtii]
GTGTCAGAAGATAAAAATTACATTCCTAAAAAAGGGGATATAGTTTGGATTGATTTTGATCCTTTAACAGGAAACGAAAT
TCAAAAGAGACGTCCAGGATTAGTTGTTTCTCGATACGAATTTAATCGAAAGACAATGTTTGCGGTAATCTGTCCAATTA
CTTCTACTATAAAGAACCTACCGACGCGCTATTCTCTGCCTGAAGATTTAGATACAAATGGGCAAGTACTTATTTCTCAA
TTAAAATCACTTGATTTCAAAGAAAGAAAACTCAAAAAGATAGAAAATTTACCTTTACAAGATATGGCTAAAATTGATCA
AGTTATTCAGTATATTTTTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8502.41 Da        Isoelectric Point: 4.0533

>AT78889 WP_096081741.1 NZ_CP022340:c2386629-2386399 [Enterococcus mundtii]
MLITKSRLQGSSVVITLPSDHGKKPSDNQEYIVVYSDDGTITLVPKIGDPFSGGEEAEYYEKDEWEELTPEGREIL

Download         Length: 231 bp

>AT78889 NZ_CP022340:c2386629-2386399 [Enterococcus mundtii]
ATGCTTATTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGATTACTCTTCCATCTGATCATGGAAAAAAACCTTCGGA
TAACCAGGAATATATCGTTGTATATTCTGATGATGGAACAATTACGTTAGTTCCTAAAATCGGTGATCCATTTAGTGGAG
GAGAAGAAGCTGAGTATTATGAAAAAGATGAATGGGAAGAGCTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References