Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4060677..4061356 Replicon chromosome
Accession NZ_CP022338
Organism Yersinia enterocolitica strain FORC066

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag FORC066_RS18685 Protein ID WP_050163692.1
Coordinates 4060677..4061018 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag FORC066_RS18690 Protein ID WP_050163693.1
Coordinates 4061045..4061356 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC066_RS18675 (FORC066_3966) 4057418..4058287 + 870 Protein_3656 DNA-protecting protein DprA -
FORC066_RS18680 (FORC066_3968) 4058645..4059757 - 1113 WP_072084067.1 IS3 family transposase -
FORC066_RS18685 (FORC066_3969) 4060677..4061018 - 342 WP_050163692.1 TA system toxin CbtA family protein Toxin
FORC066_RS18690 (FORC066_3970) 4061045..4061356 - 312 WP_050163693.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FORC066_RS18695 (FORC066_3971) 4061385..4061867 - 483 WP_050163694.1 DNA repair protein RadC -
FORC066_RS18700 4061876..4062336 - 461 Protein_3661 antirestriction protein -
FORC066_RS18705 (FORC066_3974) 4062432..4062671 - 240 WP_050163695.1 DUF905 domain-containing protein -
FORC066_RS18710 (FORC066_3975) 4062749..4063159 - 411 WP_050163696.1 hypothetical protein -
FORC066_RS18715 (FORC066_3976) 4063249..4063863 - 615 WP_050163697.1 hypothetical protein -
FORC066_RS18720 (FORC066_3977) 4063860..4064564 - 705 WP_050163698.1 WYL domain-containing protein -
FORC066_RS18725 (FORC066_3978) 4064766..4065599 - 834 WP_050163699.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4060677..4083508 22831
- flank IS/Tn - - 4058645..4059757 1112


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-102)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12823.65 Da        Isoelectric Point: 8.0308

>T78888 WP_050163692.1 NZ_CP022338:c4061018-4060677 [Yersinia enterocolitica]
MKPQPATSSRAVKPCQSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHIDAGITLADAVNFLVEKYELIRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRRNSNNSAL

Download         Length: 342 bp

>T78888 NZ_CP022338:c4061018-4060677 [Yersinia enterocolitica]
ATGAAACCTCAACCTGCAACGTCTTCGCGGGCGGTAAAGCCCTGCCAGTCACCCGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACGCTAAATGACACACCTTTCAGTGATGAAACCGTTATTCAGGAACATATCG
ACGCTGGTATCACGCTGGCCGATGCCGTTAACTTTCTGGTGGAAAAATACGAGCTGATTCGAATAGATCGCAAAGGATTT
AGCTGGCAGGAACAATCCCCTTATCTTCGGGCTGTCGATATCCTGCGGGCACGACAGGCAACTGGCTTGTTACGAAGAAA
CAGTAATAACTCTGCGTTGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11708.40 Da        Isoelectric Point: 6.9465

>AT78888 WP_050163693.1 NZ_CP022338:c4061356-4061045 [Yersinia enterocolitica]
MNEMSWGLQRDVTPRLGARLVQEGNRLHYLADRASITGKFSNAECRKLDEVFPHFISQMESMLTTGELNPRHAHCVTLYH
KGFTCEADTLGSCGYLYIVVYPI

Download         Length: 312 bp

>AT78888 NZ_CP022338:c4061356-4061045 [Yersinia enterocolitica]
ATGAATGAAATGAGCTGGGGCCTGCAGCGTGACGTCACTCCCCGTCTCGGGGCCAGGCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTGGCTGACCGGGCCAGCATCACCGGTAAATTCAGTAACGCCGAATGTCGGAAGCTGGATGAAGTATTTCCAC
ACTTTATCAGCCAGATGGAATCAATGCTGACCACCGGTGAACTGAATCCCCGACACGCACACTGCGTCACACTGTATCAC
AAAGGTTTTACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACTTATATATCGTTGTTTATCCAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References