Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2409177..2410137 Replicon chromosome
Accession NZ_CP022338
Organism Yersinia enterocolitica strain FORC066

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag FORC066_RS11080 Protein ID WP_019079355.1
Coordinates 2409679..2410137 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag FORC066_RS11075 Protein ID WP_019079356.1
Coordinates 2409177..2409623 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC066_RS11055 (FORC066_2372) 2404859..2405566 + 708 WP_057627622.1 murein tripeptide amidase MpaA -
FORC066_RS11060 (FORC066_2373) 2405563..2406534 - 972 WP_019079358.1 L-Ala-D/L-Glu epimerase -
FORC066_RS11065 (FORC066_2374) 2406687..2407190 + 504 WP_005161000.1 thiol peroxidase -
FORC066_RS11070 (FORC066_2375) 2407274..2408857 - 1584 WP_019079357.1 transcriptional regulator TyrR -
FORC066_RS11075 (FORC066_2376) 2409177..2409623 + 447 WP_019079356.1 type II toxin-antitoxin system antitoxin Xre Antitoxin
FORC066_RS11080 (FORC066_2377) 2409679..2410137 + 459 WP_019079355.1 RES family NAD+ phosphorylase Toxin
FORC066_RS11085 (FORC066_2378) 2410140..2411203 - 1064 Protein_2177 YcjF family protein -
FORC066_RS11090 (FORC066_2379) 2411200..2412597 - 1398 WP_046050953.1 YcjX family protein -
FORC066_RS11095 (FORC066_2380) 2412578..2412817 - 240 WP_005169543.1 phage shock protein PspD -
FORC066_RS11100 (FORC066_2381) 2412863..2413258 - 396 WP_161803522.1 envelope stress response membrane protein PspC -
FORC066_RS11105 (FORC066_2382) 2413267..2413494 - 228 WP_019079351.1 envelope stress response membrane protein PspB -
FORC066_RS11110 (FORC066_2383) 2413723..2414388 - 666 WP_046695022.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17205.62 Da        Isoelectric Point: 4.6956

>T78886 WP_019079355.1 NZ_CP022338:2409679-2410137 [Yersinia enterocolitica]
MMLYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIEDSNIMLLQPQ
DWPTDWRSDPAPATTMDIGTEWLESESSLGLLVPSTLVPTENNLLLNPRHKSFQACLSSVQPLSFAFDPRLK

Download         Length: 459 bp

>T78886 NZ_CP022338:2409679-2410137 [Yersinia enterocolitica]
ATGATGCTCTACCGCATTGTGATGCGCCGCTATCTTGCCTCAACCTGGACCGGCTATGGTGCCGAAATCTATGGTGGCCG
CTGGAATCATAAGGGGCACGCCGCCATCTACTTAGCCAGCAGTGTATCACTGGCGATGTTGGAGACGTTGGTACATATTC
AGGACAGCTCAACACTAAGTGAGTTCGAGTTATTCCAAATTGAAATCGAAGATAGCAACATTATGCTGCTTCAGCCGCAG
GATTGGCCCACGGACTGGCGCAGCGACCCCGCACCTGCGACCACAATGGATATCGGCACTGAATGGCTGGAGTCAGAATC
ATCACTTGGATTACTGGTTCCATCCACTCTGGTGCCGACAGAAAACAATCTACTGCTCAATCCTCGGCACAAAAGCTTTC
AAGCCTGCCTAAGCAGTGTTCAACCGCTCTCTTTTGCCTTTGACCCACGGCTGAAATAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16237.66 Da        Isoelectric Point: 9.1260

>AT78886 WP_019079356.1 NZ_CP022338:2409177-2409623 [Yersinia enterocolitica]
MRAYHPTPATKTGALWREIGLPASRGTVLVDSIKMGFSVDVIDSIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLIGRLEHGVFS

Download         Length: 447 bp

>AT78886 NZ_CP022338:2409177-2409623 [Yersinia enterocolitica]
ATGAGAGCGTATCACCCCACTCCAGCGACCAAAACAGGGGCGCTATGGCGAGAGATTGGTTTGCCCGCGAGCCGCGGTAC
TGTATTGGTCGATAGCATCAAAATGGGTTTTTCTGTTGATGTCATTGACAGCATCCATCTATGGGCATCAATCCCCAAAG
CTGAAATCTTGCGTGCGACCGGCATTCCCAGCCGCAGCTTGACTCGCAGACGCACACATGATGGCCGTTTCACTCCCGAA
GAGAGTGAGCGAATTGCGCGTTTTGTTCGGGTTATGGACGCCGCAGTTGATCTATTTGGCGGAGATAAAGGCAAAGCTAT
CACTTGGATGTCGACCCCGATTAAAGGCCTGGGTCACCGTAGTCCGGATTCCTTACTGGAAACCGAAACCGGTGCATTGG
AAGTCTGTGATTTGATTGGACGCCTGGAGCACGGCGTATTTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References