Detailed information of TA system TA078885

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2020372..2020885
• Replicon: chromosome
• Accession: NZ_CP022338
• Organism: Yersinia enterocolitica strain FORC066

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A209AEM7
• Locus tag: FORC066_RS09255
• Protein ID: WP_012105238.1
• Coordinates: 2020372..2020656 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A386HFF3
• Locus tag: FORC066_RS09260
• Protein ID: WP_012105237.1
• Coordinates: 2020646..2020885 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC066_RS09205	2015549..2015845	+	297	WP_050094911.1	hypothetical protein	-
FORC066_RS09210	2015993..2016262	+	270	WP_098057193.1	hypothetical protein	-
FORC066_RS09215 (FORC066_1974)	2016296..2016532	-	237	WP_098057500.1	ATP-dependent RNA helicase HrpA	-
FORC066_RS09220 (FORC066_1975)	2016580..2016798	-	219	WP_098057192.1	DUF2158 domain-containing protein	-
FORC066_RS09225 (FORC066_1976)	2016932..2017075	-	144	WP_193785608.1	hypothetical protein	-
FORC066_RS09230 (FORC066_1977)	2017192..2017764	+	573	WP_227747453.1	ParB/Srx family N-terminal domain-containing protein	-
FORC066_RS09235 (FORC066_1978)	2017761..2018375	+	615	WP_098057186.1	protein Mom	-
FORC066_RS09240 (FORC066_1979)	2018378..2018635	+	258	WP_098057184.1	hypothetical protein	-
FORC066_RS09245 (FORC066_1980)	2018834..2019274	-	441	WP_025378494.1	hypothetical protein	-
FORC066_RS09250 (FORC066_1981)	2019354..2020361	+	1008	WP_098057182.1	terminase small subunit	-
FORC066_RS09255 (FORC066_1982)	2020372..2020656	-	285	WP_012105238.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FORC066_RS09260 (FORC066_1983)	2020646..2020885	-	240	WP_012105237.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FORC066_RS09265	2021012..2021551	+	540	WP_260970670.1	hypothetical protein	-
FORC066_RS09270	2021524..2022294	+	771	WP_260970671.1	phage terminase large subunit	-
FORC066_RS09275 (FORC066_1985)	2022297..2023682	+	1386	WP_260970672.1	DUF1073 domain-containing protein	-
FORC066_RS09280 (FORC066_1986)	2023633..2024490	+	858	WP_260970673.1	phage minor head protein	-
FORC066_RS09285 (FORC066_1987)	2024502..2025701	+	1200	WP_260970674.1	DUF2213 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1996920..2058763	61843

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-76)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11186.99 Da
• Isoelectric Point: 10.3007

>T78885 WP_012105238.1 NZ_CP022338:c2020656-2020372 [Yersinia enterocolitica]
MTYNLDFDRRALKEWHKLGDTVRQQFKKKLLEVIKNPRVEANKLRDLPDCYKIKLRSAGYRLIYQVQDEKITVFVVAVGK
RDREEAYSEAGKRV

Nucleotide

• Length: 285 bp

>T78885 NZ_CP022338:c2020656-2020372 [Yersinia enterocolitica]
ATGACTTATAATCTTGATTTTGATCGTCGGGCGCTGAAGGAATGGCATAAGCTCGGCGATACCGTACGTCAGCAATTTAA
GAAAAAGCTGCTCGAAGTGATTAAAAATCCACGCGTTGAAGCCAATAAACTGCGCGACTTACCTGATTGCTACAAAATAA
AACTACGCAGCGCCGGGTACCGCCTGATTTATCAGGTGCAAGACGAAAAAATCACGGTTTTTGTGGTTGCCGTGGGTAAA
CGGGATCGTGAAGAAGCCTACAGTGAAGCTGGCAAGCGCGTCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8836.12 Da
• Isoelectric Point: 4.5105

>AT78885 WP_012105237.1 NZ_CP022338:c2020885-2020646 [Yersinia enterocolitica]
MGNINIRIDDDLKDRSYAVLEKLGVTPSDLLRQTLEYVAQSGKLPFKSVLLTDEDQALVAVVRERLANPQPVRVSLDDL

Nucleotide

• Length: 240 bp

>AT78885 NZ_CP022338:c2020885-2020646 [Yersinia enterocolitica]
ATGGGTAATATTAATATTCGCATCGATGATGACTTAAAAGATCGTTCTTATGCGGTACTGGAAAAACTGGGGGTCACCCC
CTCTGATTTGCTGCGCCAGACACTGGAATATGTGGCACAAAGTGGCAAACTGCCCTTTAAATCCGTGTTGCTGACCGATG
AAGATCAAGCACTGGTCGCCGTAGTCAGAGAACGTTTAGCCAATCCACAACCGGTCAGGGTGTCACTGGATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A209AEM7