78876

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 1035044..1036409 Replicon chromosome
Accession NZ_CP022338
Organism Yersinia enterocolitica strain FORC066

Toxin (Protein)


Gene name sanaT Uniprot ID -
Locus tag FORC066_RS04685 Protein ID WP_019083804.1
Coordinates 1035432..1036409 (+) Length 326 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID -
Locus tag FORC066_RS04680 Protein ID WP_046051984.1
Coordinates 1035044..1035439 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC066_RS04655 (FORC066_0979) 1030280..1031683 - 1404 WP_019083810.1 hypothetical protein -
FORC066_RS04660 (FORC066_0980) 1031990..1032493 + 504 WP_019083809.1 DUF2569 family protein -
FORC066_RS04665 (FORC066_0981) 1032761..1033321 - 561 WP_057628086.1 hypothetical protein -
FORC066_RS04670 (FORC066_0982) 1033683..1033922 - 240 WP_019083807.1 hypothetical protein -
FORC066_RS04675 (FORC066_0984) 1034521..1034901 - 381 Protein_914 Cro/Cl family transcriptional regulator -
FORC066_RS04680 (FORC066_0985) 1035044..1035439 + 396 WP_046051984.1 DUF6088 family protein Antitoxin
FORC066_RS04685 (FORC066_0986) 1035432..1036409 + 978 WP_019083804.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
FORC066_RS04690 (FORC066_0988) 1036877..1037965 - 1089 WP_046050398.1 helicase RepA family protein -
FORC066_RS04695 (FORC066_0989) 1037962..1038921 - 960 WP_046050399.1 primase-helicase zinc-binding domain-containing protein -
FORC066_RS04700 (FORC066_0990) 1038914..1039102 - 189 WP_050164266.1 hypothetical protein -
FORC066_RS04705 1039184..1039453 - 270 Protein_920 ash family protein -
FORC066_RS04710 (FORC066_0991) 1039453..1039653 - 201 WP_019082167.1 AlpA family transcriptional regulator -
FORC066_RS04715 (FORC066_0992) 1039656..1040534 - 879 WP_050916771.1 integrase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1032313..1073355 41042


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(39-298)

Antitoxin

Protein of unknown function DUF6088

(7-90)


Sequences

Toxin        


Download         Length: 326 a.a.        Molecular weight: 37452.99 Da        Isoelectric Point: 4.9500

>T78876 WP_019083804.1 NZ_CP022338:1035432-1036409 [Yersinia enterocolitica]
MDKLSMIFADVADALGIGATSIVEKDYYVIELLRLLQPLIFETHQLVFAGGTSLAKSGIKLNRMSEDVDIKLIPNPDFLD
DTHFSRSQRKNTRKEIIEKISDIIIASELFKFDKSYPRIARDEYRYNDIQIQYPQEFTQVPCLRPFIKLELMESDLLEPA
ELRNISSFVYELAGKGSEISAFPCTTIISTQAEKIVAMMRRTAAFMRNVDRKDDESLVRHIYDNYRIVDALGLNICQLSV
FVQQTIQLDIERYGCQHPQLKANAIDELKTGLDEIGSNPYFKERYGQFVVPMVFENSRVEWEEVYHCFRQTALETLKCLD
GSLTK

Download         Length: 978 bp

>T78876 NZ_CP022338:1035432-1036409 [Yersinia enterocolitica]
ATGGATAAATTATCAATGATTTTTGCAGATGTTGCCGATGCCTTGGGGATCGGTGCAACATCTATCGTTGAAAAAGATTA
TTATGTTATTGAGTTACTTCGCCTATTACAGCCTTTGATATTTGAGACACATCAACTTGTGTTTGCTGGAGGAACATCTC
TGGCGAAATCGGGTATTAAATTAAATCGGATGTCTGAGGATGTAGATATAAAACTTATCCCCAATCCGGATTTTCTTGAT
GATACCCATTTCTCGCGTTCACAACGTAAAAATACGAGAAAGGAAATTATCGAAAAAATATCAGATATTATTATTGCATC
AGAGCTATTTAAGTTCGATAAGAGCTATCCAAGAATAGCTCGGGATGAATATCGATATAATGATATTCAAATCCAATACC
CTCAAGAGTTTACTCAAGTCCCTTGTCTTAGACCTTTCATCAAGCTGGAATTAATGGAATCAGATTTGTTAGAACCGGCT
GAGTTGCGAAATATTAGTTCTTTTGTCTACGAGTTAGCAGGAAAAGGGAGCGAAATATCTGCATTTCCTTGTACAACAAT
TATCAGCACTCAAGCTGAAAAGATAGTTGCCATGATGAGGCGTACGGCTGCATTTATGAGAAATGTAGACCGCAAAGATG
ACGAATCGTTGGTTCGCCATATTTACGATAATTATCGCATTGTTGATGCCTTGGGTTTAAATATTTGTCAGCTATCAGTT
TTTGTGCAACAGACGATTCAACTAGATATTGAGCGTTATGGATGCCAGCATCCGCAATTGAAAGCGAATGCTATAGATGA
ACTTAAAACGGGATTAGACGAGATTGGTAGTAACCCCTATTTTAAAGAGCGCTATGGGCAGTTTGTGGTTCCAATGGTAT
TTGAGAATAGCAGGGTTGAATGGGAAGAGGTTTATCACTGTTTTCGTCAGACGGCATTGGAAACTTTGAAATGTTTAGAT
GGCTCATTAACTAAGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14812.09 Da        Isoelectric Point: 10.7908

>AT78876 WP_046051984.1 NZ_CP022338:1035044-1035439 [Yersinia enterocolitica]
MTIKERIQTRLKRSKRYVFTRDDFKDIADYDQIGRVLRNLVKEGLLLRVGYGLYTKARKNSITGKIMPASPGGSDAVILE
SLDRLNVHYTLDASTTKYIKGETTQVPAYTQVKTSPRFKRALSVGNSRLNG

Download         Length: 396 bp

>AT78876 NZ_CP022338:1035044-1035439 [Yersinia enterocolitica]
ATGACTATCAAAGAACGTATTCAAACGAGATTAAAACGTTCTAAACGTTACGTGTTTACTCGTGATGATTTCAAAGATAT
TGCTGATTACGATCAGATTGGTCGCGTGTTGCGTAATCTAGTGAAAGAAGGATTATTGCTTAGGGTGGGGTATGGACTGT
ACACCAAAGCGCGTAAGAACTCGATCACTGGTAAGATCATGCCTGCCTCTCCTGGCGGTTCTGACGCAGTTATTCTTGAG
TCACTTGACCGTTTGAATGTTCATTACACATTGGATGCCAGCACGACTAAGTATATAAAAGGTGAAACAACGCAAGTACC
TGCTTACACTCAAGTCAAGACGTCGCCTCGCTTCAAACGTGCATTGTCCGTTGGGAATAGCAGATTGAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References