Detailed information of TA system TA078875

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 790828..791500
• Replicon: chromosome
• Accession: NZ_CP022338
• Organism: Yersinia enterocolitica strain FORC066

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: FORC066_RS03510
• Protein ID: WP_046050300.1
• Coordinates: 791075..791500 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A7U7FJE4
• Locus tag: FORC066_RS03505
• Protein ID: WP_004390965.1
• Coordinates: 790828..791094 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC066_RS03480 (FORC066_0736)	786799..787236	+	438	WP_019082405.1	lipocalin-like domain-containing protein	-
FORC066_RS03485 (FORC066_0737)	787252..788001	+	750	WP_019078990.1	SDR family oxidoreductase	-
FORC066_RS03490 (FORC066_0738)	788014..788616	-	603	WP_011817027.1	HD domain-containing protein	-
FORC066_RS03495 (FORC066_0739)	788854..789537	+	684	WP_019082407.1	hemolysin III family protein	-
FORC066_RS03500 (FORC066_0740)	789570..790562	-	993	WP_046050299.1	tRNA-modifying protein YgfZ	-
FORC066_RS03505 (FORC066_0741)	790828..791094	+	267	WP_004390965.1	FAD assembly factor SdhE	Antitoxin
FORC066_RS03510 (FORC066_0742)	791075..791500	+	426	WP_046050300.1	protein YgfX	Toxin
FORC066_RS03515 (FORC066_0743)	791500..792198	+	699	WP_011817024.1	two-component system response regulator CreB	-
FORC066_RS03520 (FORC066_0744)	792209..793636	+	1428	WP_019078986.1	two-component system sensor histidine kinase CreC	-
FORC066_RS03525 (FORC066_0745)	793728..795149	+	1422	WP_046694580.1	cell envelope integrity protein CreD	-
FORC066_RS03530 (FORC066_0746)	795221..795739	-	519	WP_057627940.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-133)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 16452.24 Da
• Isoelectric Point: 9.8217

>T78875 WP_046050300.1 NZ_CP022338:791075-791500 [Yersinia enterocolitica]
VAQWRCDLRISWHTQLFSLLAHGVLVTLTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNIVLWKRH
EWVVIKQPWITRYGVLLSLQQTSNRSTRKRLWLAADSMSEEEWRQLCLLLRHSFGSDEGIN

Nucleotide

• Length: 426 bp

>T78875 NZ_CP022338:791075-791500 [Yersinia enterocolitica]
GTGGCCCAGTGGCGATGTGACCTGCGGATATCCTGGCACACTCAACTCTTCTCTCTATTAGCTCATGGCGTCCTGGTCAC
ACTGACGCTGGTTGCGCCTTGGCCTCAGGGCTATACCGCGCTGTGGTTGGTGTTACTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAATATCACGTCTTGCCAAGGCGAGATCAGGCTGAAACCCGGCAATATAGTGCTATGGAAACGGCAT
GAGTGGGTTGTCATTAAGCAGCCGTGGATCACCCGTTATGGCGTGTTATTGAGTTTACAACAGACAAGCAACCGCTCAAC
CCGTAAGCGTTTATGGTTAGCGGCTGATAGCATGTCTGAAGAGGAATGGCGGCAATTGTGTCTCCTGTTGCGCCATTCAT
TTGGCTCCGATGAAGGTATTAATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10491.01 Da
• Isoelectric Point: 5.1405

>AT78875 WP_004390965.1 NZ_CP022338:790828-791094 [Yersinia enterocolitica]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT78875 NZ_CP022338:790828-791094 [Yersinia enterocolitica]
ATGGAAATCGATAATAAAGCCCGTATCCACTGGGCGTGCCGTCGGGGTATGCGTGAACTGGATATCTCTATCATGCCGTT
TTTTGAACATGAATATGATGGCTTGAGCGATAACGAGAAACAGGTTTTTATCCGTTTGCTTGAGTGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCACGGGGAACCGCAGGATAGTGAGCTGCGTCAAATGGTCAAACTGATTCAAACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U7FJE4