Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3249019..3249600 Replicon chromosome
Accession NZ_CP022336
Organism Sphingorhabdus sp. SMR4y

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag SPHFLASMR4Y_RS15660 Protein ID WP_089134378.1
Coordinates 3249019..3249201 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag SPHFLASMR4Y_RS15665 Protein ID WP_089134379.1
Coordinates 3249214..3249600 (+) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPHFLASMR4Y_RS15650 3245116..3247059 - 1944 WP_089134376.1 S9 family peptidase -
SPHFLASMR4Y_RS15655 3247131..3248987 + 1857 WP_089134377.1 aminodeoxychorismate synthase component I -
SPHFLASMR4Y_RS15660 3249019..3249201 + 183 WP_089134378.1 type II toxin-antitoxin system HicA family toxin Toxin
SPHFLASMR4Y_RS15665 3249214..3249600 + 387 WP_089134379.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SPHFLASMR4Y_RS15670 3249834..3250091 + 258 WP_089134380.1 type II toxin-antitoxin system RelE/ParE family toxin -
SPHFLASMR4Y_RS15675 3250158..3250748 + 591 WP_089134381.1 helix-turn-helix transcriptional regulator -
SPHFLASMR4Y_RS15680 3251134..3251808 + 675 WP_089134382.1 hypothetical protein -
SPHFLASMR4Y_RS15685 3251965..3252921 + 957 WP_089134383.1 sulfite exporter TauE/SafE family protein -
SPHFLASMR4Y_RS15690 3253048..3254055 + 1008 WP_089134384.1 DNA topoisomerase IB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-121)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7035.31 Da        Isoelectric Point: 11.8166

>T78873 WP_089134378.1 NZ_CP022336:3249019-3249201 [Sphingorhabdus sp. SMR4y]
MERSSKQIIRRLRKEGFELVSIRGSHHKYRKDDRIIIVPHPKKDLPVGTARSIARMAGWI

Download         Length: 183 bp

>T78873 NZ_CP022336:3249019-3249201 [Sphingorhabdus sp. SMR4y]
ATGGAGCGGAGCAGCAAGCAGATCATCCGGCGGCTCCGCAAGGAGGGCTTTGAACTGGTTTCAATCAGAGGCTCTCACCA
TAAATATCGTAAGGATGATCGTATCATCATTGTCCCGCATCCCAAGAAAGACCTGCCCGTCGGGACGGCGCGCAGCATCG
CCCGGATGGCGGGATGGATTTGA

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 13871.70 Da        Isoelectric Point: 4.2881

>AT78873 WP_089134379.1 NZ_CP022336:3249214-3249600 [Sphingorhabdus sp. SMR4y]
MFYFAVVHKDEDSAFGISFPDVPGCFSAADEEGDIIANAIEALSLYFEDEEMVPASPIGAIQKSAAEDLKQGAFLVQIPY
LQRTGRTGRYNVSLDTGVVKMIDSAARTRKMTRSAFLEDAALKEIGVG

Download         Length: 387 bp

>AT78873 NZ_CP022336:3249214-3249600 [Sphingorhabdus sp. SMR4y]
ATGTTCTATTTTGCCGTCGTGCATAAGGATGAAGACAGCGCTTTCGGAATTTCCTTTCCGGATGTGCCCGGCTGCTTTTC
CGCGGCGGACGAGGAAGGCGATATTATCGCCAATGCAATCGAGGCGCTGTCACTCTATTTTGAGGATGAAGAGATGGTCC
CCGCCAGCCCGATCGGCGCAATCCAGAAATCAGCCGCCGAGGATCTGAAGCAGGGCGCGTTTCTGGTGCAGATCCCCTAT
CTGCAGCGCACCGGCCGGACCGGTCGCTATAATGTCTCGCTCGACACCGGCGTCGTCAAAATGATCGACAGCGCCGCCCG
CACCCGAAAAATGACCCGCAGCGCCTTTCTGGAGGATGCGGCGTTGAAGGAGATTGGGGTGGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References