Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1272823..1273412 Replicon chromosome
Accession NZ_CP022336
Organism Sphingorhabdus sp. SMR4y

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag SPHFLASMR4Y_RS06005 Protein ID WP_089132748.1
Coordinates 1273110..1273412 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag SPHFLASMR4Y_RS06000 Protein ID WP_089132747.1
Coordinates 1272823..1273110 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPHFLASMR4Y_RS05985 1268542..1269354 + 813 WP_089132744.1 rRNA pseudouridine synthase -
SPHFLASMR4Y_RS05990 1269451..1269987 + 537 WP_089132745.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
SPHFLASMR4Y_RS05995 1270251..1272569 + 2319 WP_089132746.1 UvrD-helicase domain-containing protein -
SPHFLASMR4Y_RS06000 1272823..1273110 - 288 WP_089132747.1 putative addiction module antidote protein Antitoxin
SPHFLASMR4Y_RS06005 1273110..1273412 - 303 WP_089132748.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SPHFLASMR4Y_RS06010 1273638..1273880 - 243 WP_089132749.1 hypothetical protein -
SPHFLASMR4Y_RS17040 1273903..1274043 - 141 WP_186266055.1 hypothetical protein -
SPHFLASMR4Y_RS06015 1274321..1274953 - 633 WP_089134715.1 L,D-transpeptidase family protein -
SPHFLASMR4Y_RS06020 1275169..1276485 + 1317 WP_089132750.1 MFS transporter -
SPHFLASMR4Y_RS06025 1276510..1277430 + 921 WP_089132751.1 cysteine synthase A -
SPHFLASMR4Y_RS06030 1277427..1278167 + 741 WP_089132752.1 dienelactone hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(7-93)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11326.09 Da        Isoelectric Point: 10.8545

>T78872 WP_089132748.1 NZ_CP022336:c1273412-1273110 [Sphingorhabdus sp. SMR4y]
MVEIVRSQTFVHWLKRLKDRRAIAKIVQRIDRLSLGNFGDVKSVGGGVSELRVDHGPGYRLYFARRQNGEIVILLCGGTK
KRQNADIAGAQEMARNNEIY

Download         Length: 303 bp

>T78872 NZ_CP022336:c1273412-1273110 [Sphingorhabdus sp. SMR4y]
ATGGTTGAGATTGTCCGCAGTCAGACATTCGTCCACTGGTTGAAACGGCTCAAGGACCGAAGAGCGATCGCGAAAATTGT
CCAGCGCATCGACCGTCTGTCACTGGGCAATTTCGGGGACGTGAAGTCGGTTGGTGGTGGTGTGAGTGAATTGCGGGTTG
ACCATGGTCCGGGATATCGGCTCTATTTTGCGCGGCGGCAGAATGGGGAAATTGTCATACTGCTCTGCGGCGGGACGAAG
AAACGGCAAAATGCCGATATCGCCGGCGCGCAGGAGATGGCGAGAAATAATGAGATTTATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10273.69 Da        Isoelectric Point: 4.1061

>AT78872 WP_089132747.1 NZ_CP022336:c1273110-1272823 [Sphingorhabdus sp. SMR4y]
MAEQLDLKPWDATEFLDSEEMISEYLAVAFEEGDAEEIRIALNNVARARGMSDLQKETGLSRSALYKALGEGGNPTLDTL
LAIVKALGVKMSVVG

Download         Length: 288 bp

>AT78872 NZ_CP022336:c1273110-1272823 [Sphingorhabdus sp. SMR4y]
ATGGCTGAACAGTTGGACCTTAAGCCGTGGGATGCAACGGAATTCCTCGATAGTGAGGAAATGATCTCGGAATATCTCGC
CGTGGCGTTCGAGGAAGGCGATGCGGAAGAAATACGGATTGCCCTCAACAATGTCGCCCGCGCACGCGGCATGAGTGATC
TGCAAAAAGAGACCGGCCTGTCGCGTTCGGCGCTCTACAAGGCGCTGGGCGAGGGCGGCAATCCGACGCTCGATACGCTG
CTGGCGATAGTGAAGGCGCTGGGGGTGAAGATGTCGGTGGTGGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References