78871

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 543232..543868 Replicon chromosome
Accession NZ_CP022319
Organism Bacillus altitudinis strain SGAir0031

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag CFN77_RS02590 Protein ID WP_003214169.1
Coordinates 543518..543868 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A267X601
Locus tag CFN77_RS02585 Protein ID WP_012008995.1
Coordinates 543232..543513 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFN77_RS02565 539379..539984 - 606 WP_007496491.1 rhomboid family intramembrane serine protease -
CFN77_RS02570 540079..540444 + 366 WP_041092976.1 holo-ACP synthase -
CFN77_RS02575 540605..541621 + 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
CFN77_RS02580 541757..542938 + 1182 WP_096881040.1 alanine racemase -
CFN77_RS02585 543232..543513 + 282 WP_012008995.1 hypothetical protein Antitoxin
CFN77_RS02590 543518..543868 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
CFN77_RS02595 543983..544813 + 831 WP_017358395.1 STAS domain-containing protein -
CFN77_RS02600 544818..545186 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
CFN77_RS02605 545189..545590 + 402 WP_003214085.1 anti-sigma regulatory factor -
CFN77_RS02610 545601..546608 + 1008 WP_017358394.1 PP2C family protein-serine/threonine phosphatase -
CFN77_RS02615 546668..546997 + 330 WP_017358393.1 anti-sigma factor antagonist -
CFN77_RS02620 546994..547482 + 489 WP_024719203.1 anti-sigma B factor RsbW -
CFN77_RS02625 547448..548236 + 789 WP_012009000.1 RNA polymerase sigma factor SigB -
CFN77_RS02630 548236..548835 + 600 WP_024719202.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T78871 WP_003214169.1 NZ_CP022319:543518-543868 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T78871 NZ_CP022319:543518-543868 [Bacillus altitudinis]
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCAGT
ATTGGTGATTCAAAATGACATTGGAAATCGCTTCAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTAATGCAAAGCGCTACGGCTTTGAACGAGATTCTGTCATTCTTTTGGAACAGATT
CGTACGATCGATAAACAAAGATTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10894.27 Da        Isoelectric Point: 5.2726

>AT78871 WP_012008995.1 NZ_CP022319:543232-543513 [Bacillus altitudinis]
MSESSATNEMKIRLPETLMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT78871 NZ_CP022319:543232-543513 [Bacillus altitudinis]
TTGTCTGAATCCAGCGCGACAAACGAAATGAAGATTCGACTGCCGGAGACTTTGATGTCTGAGATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGTAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAAGCACAATACGCAGAGTTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A267X601

References