Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 839955..840610 Replicon chromosome
Accession NZ_CP022316
Organism Brachybacterium avium strain VR2415

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CFK39_RS03805 Protein ID WP_089064344.1
Coordinates 839955..840380 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CFK39_RS03810 Protein ID WP_089064345.1
Coordinates 840377..840610 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFK39_RS03770 835630..836415 + 786 WP_089064339.1 ferritin-like domain-containing protein -
CFK39_RS03775 836519..837238 + 720 WP_172805638.1 MSMEG_4193 family putative phosphomutase -
CFK39_RS03780 837235..837783 + 549 WP_089064340.1 DUF3090 domain-containing protein -
CFK39_RS03785 837783..838550 + 768 WP_089064341.1 SCO1664 family protein -
CFK39_RS03790 838645..838899 - 255 WP_089064342.1 Txe/YoeB family addiction module toxin -
CFK39_RS03795 838900..839160 - 261 WP_089064343.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
CFK39_RS03800 839407..839958 - 552 Protein_740 GNAT family N-acetyltransferase -
CFK39_RS03805 839955..840380 - 426 WP_089064344.1 type II toxin-antitoxin system VapC family toxin Toxin
CFK39_RS03810 840377..840610 - 234 WP_089064345.1 Arc family DNA-binding protein Antitoxin
CFK39_RS03815 840758..841843 - 1086 WP_089064346.1 redox-regulated ATPase YchF -
CFK39_RS03820 841964..842788 - 825 WP_089064347.1 hypothetical protein -
CFK39_RS03825 842868..843956 - 1089 WP_089064348.1 hypothetical protein -
CFK39_RS03830 844107..844514 + 408 WP_089064349.1 hypothetical protein -
CFK39_RS03835 844536..845186 - 651 WP_089064350.1 NAD(P)H-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(13-40)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15187.24 Da        Isoelectric Point: 4.4879

>T78870 WP_089064344.1 NZ_CP022316:c840380-839955 [Brachybacterium avium]
VIILDTNVISEIFRPLPEPRVVDWLASLEGDVAITSVTLAELLAGVRRLPDGRRRDELTRSIDAALAPYRGGRAVLPFDD
VAADRYADVLVARESTGAPISTADAQIAAICLAHGAICATRNVKDFQHTGVELVDPWNVDS

Download         Length: 426 bp

>T78870 NZ_CP022316:c840380-839955 [Brachybacterium avium]
GTGATCATTCTCGACACGAACGTGATCTCGGAGATCTTTCGACCGCTGCCTGAGCCACGCGTGGTGGACTGGCTCGCGTC
CCTGGAGGGCGACGTCGCGATTACTTCCGTCACGCTCGCGGAACTGTTGGCGGGTGTGCGACGGCTACCGGACGGTCGGC
GCAGGGATGAGCTGACCAGGAGCATCGACGCGGCGCTCGCGCCGTACCGGGGCGGCCGCGCTGTGCTGCCGTTCGACGAC
GTGGCGGCCGACCGCTACGCCGACGTGCTCGTGGCTCGAGAGAGCACGGGAGCGCCGATCAGTACCGCCGACGCGCAGAT
CGCCGCGATCTGCCTGGCGCACGGAGCAATATGCGCTACGCGCAATGTGAAGGATTTCCAGCACACCGGCGTCGAACTGG
TGGACCCGTGGAATGTCGACTCGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8184.43 Da        Isoelectric Point: 6.4613

>AT78870 WP_089064345.1 NZ_CP022316:c840610-840377 [Brachybacterium avium]
MSSIIVRGLDAAVKQQLAAQAKEHGRSMEAEVRAILTKAARRPHIGIALLAAAQDVGGVEDLPIPVRDDVARAVDFE

Download         Length: 234 bp

>AT78870 NZ_CP022316:c840610-840377 [Brachybacterium avium]
ATGTCATCCATCATCGTCCGCGGTCTCGACGCCGCCGTGAAACAGCAACTCGCCGCGCAGGCTAAGGAGCACGGTCGGTC
CATGGAAGCCGAGGTTCGCGCCATCCTTACCAAGGCTGCACGCAGGCCGCACATCGGAATCGCTCTACTGGCTGCCGCGC
AGGATGTCGGTGGAGTCGAAGATCTGCCGATCCCTGTGCGCGATGACGTCGCACGGGCGGTGGACTTCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References