78868

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 632846..633491 Replicon chromosome
Accession NZ_CP022315
Organism Virgibacillus phasianinus strain LM2416

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CFK37_RS03180 Protein ID WP_089060530.1
Coordinates 632846..633196 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag CFK37_RS03185 Protein ID WP_172840446.1
Coordinates 633201..633491 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFK37_RS03145 628296..629081 - 786 WP_089060524.1 RNA polymerase sigma factor SigB -
CFK37_RS03150 629053..629529 - 477 WP_089060525.1 anti-sigma B factor RsbW -
CFK37_RS03155 629529..629861 - 333 WP_089060526.1 STAS domain-containing protein -
CFK37_RS03160 629968..630963 - 996 WP_089063522.1 PP2C family protein-serine/threonine phosphatase -
CFK37_RS03165 630999..631400 - 402 WP_089060527.1 anti-sigma regulatory factor -
CFK37_RS03170 631403..631759 - 357 WP_089060528.1 STAS domain-containing protein -
CFK37_RS03175 631766..632635 - 870 WP_089060529.1 RsbT co-antagonist protein RsbRA -
CFK37_RS03180 632846..633196 - 351 WP_089060530.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CFK37_RS03185 633201..633491 - 291 WP_172840446.1 antitoxin Antitoxin
CFK37_RS03190 633667..634797 - 1131 WP_089063523.1 alanine racemase -
CFK37_RS03195 635053..636072 - 1020 WP_089060532.1 outer membrane lipoprotein carrier protein LolA -
CFK37_RS03200 636129..637628 - 1500 WP_089060533.1 NAD(P)H-hydrate dehydratase -
CFK37_RS03205 637734..638090 - 357 WP_089060534.1 holo-ACP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13007.21 Da        Isoelectric Point: 9.5926

>T78868 WP_089060530.1 NZ_CP022315:c633196-632846 [Virgibacillus phasianinus]
MIVQRGEVYFADLSPVVGSEQGGIRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKRYGFDRNSVILLEQI
RTLDKQRLTDKITKLDSEMMKKIDQALEISLGLKDM

Download         Length: 351 bp

>T78868 NZ_CP022315:c633196-632846 [Virgibacillus phasianinus]
TTGATCGTTCAACGAGGAGAAGTATATTTCGCTGACTTATCCCCTGTGGTAGGATCAGAACAGGGAGGTATACGTCCAGT
ATTAATTTTACAAAACGATATCGGTAATAGGTTTAGCCCTACTGTAATTGTTGCAGCAATTACTGCTCAAATCCAGAAGG
CAAAGCTACCAACACATGTTGAGATTAATGCGAAGCGCTATGGTTTTGACCGTAATTCTGTTATATTACTCGAGCAAATT
CGTACGTTAGATAAACAAAGATTAACAGATAAAATTACAAAACTGGATAGTGAAATGATGAAAAAAATAGATCAGGCATT
GGAAATAAGTCTTGGACTTAAGGATATGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11230.68 Da        Isoelectric Point: 4.3640

>AT78868 WP_172840446.1 NZ_CP022315:c633491-633201 [Virgibacillus phasianinus]
MVLSESLQEILVRLPKNLLNEVDGLMKYDNRDLSDFICQATRNYLEQKKYDHIQQFRESMQKGYEEMARINLTIASEAFQ
AEEEAENTLERSVIGV

Download         Length: 291 bp

>AT78868 NZ_CP022315:c633491-633201 [Virgibacillus phasianinus]
ATGGTTTTGTCAGAGAGCTTACAGGAGATTTTAGTACGATTACCAAAAAACCTATTAAATGAGGTGGATGGACTAATGAA
GTATGATAATAGAGATCTTAGCGATTTTATCTGTCAAGCAACAAGGAATTATTTAGAACAGAAGAAATATGACCATATTC
AACAATTTCGGGAATCCATGCAAAAAGGCTATGAGGAAATGGCTCGAATTAATCTAACAATTGCGTCGGAGGCTTTTCAA
GCTGAAGAGGAGGCTGAAAACACCCTTGAGCGTTCTGTGATCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References