Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 632846..633491 Replicon chromosome
Accession NZ_CP022315
Organism Virgibacillus phasianinus strain LM2416

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CFK37_RS03180 Protein ID WP_089060530.1
Coordinates 632846..633196 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag CFK37_RS03185 Protein ID WP_172840446.1
Coordinates 633201..633491 (-) Length 97 a.a.

Genomic Context

CFK37_RS03145CFK37_RS03150CFK37_RS03155CFK37_RS03160CFK37_RS03165CFK37_RS03170CFK37_RS03175CFK37_RS03180CFK37_RS03185CFK37_RS03190CFK37_RS03195CFK37_RS03200CFK37_RS03205
Location: 628296..629081 (786 bp)
Type: Others
Protein ID: WP_089060524.1
Location: 629053..629529 (477 bp)
Type: Others
Protein ID: WP_089060525.1
Location: 629529..629861 (333 bp)
Type: Others
Protein ID: WP_089060526.1
Location: 629968..630963 (996 bp)
Type: Others
Protein ID: WP_089063522.1
Location: 630999..631400 (402 bp)
Type: Others
Protein ID: WP_089060527.1
Location: 631403..631759 (357 bp)
Type: Others
Protein ID: WP_089060528.1
Location: 631766..632635 (870 bp)
Type: Others
Protein ID: WP_089060529.1
Location: 632846..633196 (351 bp)
Type: Toxin
Protein ID: WP_089060530.1
Location: 633201..633491 (291 bp)
Type: Antitoxin
Protein ID: WP_172840446.1
Location: 633667..634797 (1131 bp)
Type: Others
Protein ID: WP_089063523.1
Location: 635053..636072 (1020 bp)
Type: Others
Protein ID: WP_089060532.1
Location: 636129..637628 (1500 bp)
Type: Others
Protein ID: WP_089060533.1
Location: 637734..638090 (357 bp)
Type: Others
Protein ID: WP_089060534.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CFK37_RS03145628296..629081-786WP_089060524.1RNA polymerase sigma factor SigB-
CFK37_RS03150629053..629529-477WP_089060525.1anti-sigma B factor RsbW-
CFK37_RS03155629529..629861-333WP_089060526.1STAS domain-containing protein-
CFK37_RS03160629968..630963-996WP_089063522.1PP2C family protein-serine/threonine phosphatase-
CFK37_RS03165630999..631400-402WP_089060527.1anti-sigma regulatory factor-
CFK37_RS03170631403..631759-357WP_089060528.1STAS domain-containing protein-
CFK37_RS03175631766..632635-870WP_089060529.1RsbT co-antagonist protein RsbRA-
CFK37_RS03180632846..633196-351WP_089060530.1type II toxin-antitoxin system PemK/MazF family toxinToxin
CFK37_RS03185633201..633491-291WP_172840446.1antitoxinAntitoxin
CFK37_RS03190633667..634797-1131WP_089063523.1alanine racemase-
CFK37_RS03195635053..636072-1020WP_089060532.1outer membrane lipoprotein carrier protein LolA-
CFK37_RS03200636129..637628-1500WP_089060533.1NAD(P)H-hydrate dehydratase-
CFK37_RS03205637734..638090-357WP_089060534.1holo-ACP synthase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13007.21 Da        Isoelectric Point: 9.5926

>T78868 WP_089060530.1 NZ_CP022315:c633196-632846 [Virgibacillus phasianinus]
MIVQRGEVYFADLSPVVGSEQGGIRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKRYGFDRNSVILLEQI
RTLDKQRLTDKITKLDSEMMKKIDQALEISLGLKDM

Download         Length: 351 bp

>T78868 NZ_CP022315:c633196-632846 [Virgibacillus phasianinus]
TTGATCGTTCAACGAGGAGAAGTATATTTCGCTGACTTATCCCCTGTGGTAGGATCAGAACAGGGAGGTATACGTCCAGT
ATTAATTTTACAAAACGATATCGGTAATAGGTTTAGCCCTACTGTAATTGTTGCAGCAATTACTGCTCAAATCCAGAAGG
CAAAGCTACCAACACATGTTGAGATTAATGCGAAGCGCTATGGTTTTGACCGTAATTCTGTTATATTACTCGAGCAAATT
CGTACGTTAGATAAACAAAGATTAACAGATAAAATTACAAAACTGGATAGTGAAATGATGAAAAAAATAGATCAGGCATT
GGAAATAAGTCTTGGACTTAAGGATATGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11230.68 Da        Isoelectric Point: 4.3640

>AT78868 WP_172840446.1 NZ_CP022315:c633491-633201 [Virgibacillus phasianinus]
MVLSESLQEILVRLPKNLLNEVDGLMKYDNRDLSDFICQATRNYLEQKKYDHIQQFRESMQKGYEEMARINLTIASEAFQ
AEEEAENTLERSVIGV

Download         Length: 291 bp

>AT78868 NZ_CP022315:c633491-633201 [Virgibacillus phasianinus]
ATGGTTTTGTCAGAGAGCTTACAGGAGATTTTAGTACGATTACCAAAAAACCTATTAAATGAGGTGGATGGACTAATGAA
GTATGATAATAGAGATCTTAGCGATTTTATCTGTCAAGCAACAAGGAATTATTTAGAACAGAAGAAATATGACCATATTC
AACAATTTCGGGAATCCATGCAAAAAGGCTATGAGGAAATGGCTCGAATTAATCTAACAATTGCGTCGGAGGCTTTTCAA
GCTGAAGAGGAGGCTGAAAACACCCTTGAGCGTTCTGTGATCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References