Detailed information of TA system TA078865

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 509669..510318
• Replicon: chromosome
• Accession: NZ_CP022298
• Organism: Acinetobacter johnsonii strain IC001

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: CFH90_RS02570
• Protein ID: WP_126035203.1
• Coordinates: 509932..510318 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9CU98
• Locus tag: CFH90_RS02565
• Protein ID: WP_004977895.1
• Coordinates: 509669..509926 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFH90_RS02545	505288..505653	+	366	WP_004691290.1	50S ribosomal protein L17	-
CFH90_RS02550	505848..507338	+	1491	WP_126035197.1	NAD(P)/FAD-dependent oxidoreductase	-
CFH90_RS02555	507478..508269	+	792	WP_126035199.1	alpha/beta hydrolase	-
CFH90_RS02560	508304..509476	-	1173	WP_126035201.1	acyl-CoA dehydrogenase family protein	-
CFH90_RS02565	509669..509926	+	258	WP_004977895.1	succinate dehydrogenase assembly factor 2	Antitoxin
CFH90_RS02570	509932..510318	+	387	WP_126035203.1	hypothetical protein	Toxin
CFH90_RS02575	511074..511316	+	243	WP_164836568.1	hypothetical protein	-
CFH90_RS18450	511313..511876	+	564	WP_078389879.1	hypothetical protein	-
CFH90_RS02580	511948..512520	+	573	WP_126035205.1	rhombosortase	-
CFH90_RS02585	512703..514979	+	2277	WP_126035207.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-127)

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15317.30 Da
• Isoelectric Point: 10.2753

>T78865 WP_126035203.1 NZ_CP022298:509932-510318 [Acinetobacter johnsonii]
MEHRHFQLKPSRLAYVFQLSIYAVLMLVLYQLLPLGLWLIALVAGFVLYLFFLRGPQHFQLQHLDGRDWSLSLQKETNVQ
RVQISHIVDHRAYIVIYFQHFRAKPMLVWCDQLPITQWKALKILTKMQ

Nucleotide

• Length: 387 bp

>T78865 NZ_CP022298:509932-510318 [Acinetobacter johnsonii]
ATGGAACATCGTCATTTTCAACTTAAACCCAGCCGTCTGGCTTATGTGTTTCAGTTGTCGATTTATGCCGTTCTGATGCT
GGTCTTGTATCAGCTACTTCCTTTAGGACTGTGGCTGATCGCTTTGGTTGCTGGCTTTGTGCTGTATTTGTTTTTTCTAC
GTGGGCCGCAACATTTTCAGCTTCAGCATTTAGATGGTCGTGATTGGTCTTTGTCACTTCAGAAAGAAACCAATGTGCAA
CGAGTGCAAATCAGCCATATTGTGGATCATCGTGCTTATATTGTGATTTATTTTCAACACTTTAGAGCAAAACCGATGTT
GGTTTGGTGTGATCAGTTACCCATCACGCAATGGAAAGCCCTGAAAATACTCACTAAAATGCAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10181.71 Da
• Isoelectric Point: 4.7119

>AT78865 WP_004977895.1 NZ_CP022298:509669-509926 [Acinetobacter johnsonii]
MTEEMSLEERKVIYRARRGLKEIDVYFDPYVKNYYLQADPAEKAMFAALVEQEDPDLLDWFMEVSEPPRPEMKTLIQKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT78865 NZ_CP022298:509669-509926 [Acinetobacter johnsonii]
ATGACTGAAGAAATGAGCCTAGAAGAGCGTAAAGTAATTTATCGTGCACGTCGTGGTTTAAAAGAAATTGATGTGTACTT
TGACCCTTATGTGAAAAATTATTATCTTCAGGCAGATCCTGCGGAAAAGGCCATGTTTGCGGCCTTGGTTGAACAAGAGG
ATCCAGATTTGTTGGATTGGTTTATGGAAGTCTCTGAGCCGCCACGCCCTGAAATGAAAACCTTGATTCAAAAATTAAAG
CATTATGTACACGGATAA

Structures

Antitoxin

• AlphaFold DB: N9CU98