Detailed information of TA system TA078864

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 279781..280309
• Replicon: chromosome
• Accession: NZ_CP022298
• Organism: Acinetobacter johnsonii strain IC001

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CFH90_RS01340
• Protein ID: WP_119686978.1
• Coordinates: 279781..280074 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: N9B5Q7
• Locus tag: CFH90_RS01345
• Protein ID: WP_000246756.1
• Coordinates: 280064..280309 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFH90_RS01310	275075..275587	-	513	Protein_248	hypothetical protein	-
CFH90_RS01325	277034..278253	+	1220	WP_126034960.1	IS3 family transposase	-
CFH90_RS01330	278478..279610	-	1133	Protein_251	IS3 family transposase	-
CFH90_RS01340	279781..280074	-	294	WP_119686978.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CFH90_RS01345	280064..280309	-	246	WP_000246756.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CFH90_RS01350	280516..281463	-	948	WP_126034964.1	sensor domain-containing diguanylate cyclase	-
CFH90_RS01355	281645..283165	-	1521	WP_005249302.1	catalase	-
CFH90_RS01360	283864..285198	+	1335	WP_126034967.1	ISNCY family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	katA	261688..313785	52097
	-	inside	IScluster/Tn	-	katA	272610..285198	12588

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11319.59 Da
• Isoelectric Point: 10.5382

>T78864 WP_119686978.1 NZ_CP022298:c280074-279781 [Acinetobacter johnsonii]
MTYKLLRHKDFKAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Nucleotide

• Length: 294 bp

>T78864 NZ_CP022298:c280074-279781 [Acinetobacter johnsonii]
ATGACTTATAAGCTTTTACGTCACAAAGACTTTAAAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
GAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGGGATCTTGCAGGTTGCTATAAAA
TTAAATTATTAAAAGCTGGTGTCAGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCTTGCTCATCACAGTCGGG
AAACGAGCTGATAGCATAGTTTATGACGAAGCTAAAAAGCGCATTAAAGACTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9235.61 Da
• Isoelectric Point: 4.3142

>AT78864 WP_000246756.1 NZ_CP022298:c280309-280064 [Acinetobacter johnsonii]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Nucleotide

• Length: 246 bp

>AT78864 NZ_CP022298:c280309-280064 [Acinetobacter johnsonii]
ATGGCTACTGTTAACTTCAGGGTCGATGAAGCCCTTAAAGAAAAATCCTATTCCATCCTTAAAGAACAAGGTATTGCACC
TACAGATTTCTTTACTAGTATTCTTGAATATGTTGCTACGACTGGGAAACTACCTGTCAAAAAAGCTCTGCTTTCAGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAGCGCATTAATGACCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Structures

Antitoxin

• AlphaFold DB: N9B5Q7