Detailed information of TA system TA078859

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 1637464..1637974
• Replicon: chromosome
• Accession: NZ_CP022297
• Organism: Marinobacterium georgiense strain IC961

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CFI10_RS07905
• Protein ID: WP_206841147.1
• Coordinates: 1637711..1637974 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: CFI10_RS07900
• Protein ID: WP_206841146.1
• Coordinates: 1637464..1637718 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFI10_RS07865	1633071..1634375	+	1305	WP_206837229.1	IS1380 family transposase	-
CFI10_RS07870	1634592..1634912	+	321	WP_206841141.1	hypothetical protein	-
CFI10_RS07875	1634905..1635474	+	570	WP_206841142.1	hypothetical protein	-
CFI10_RS07880	1635503..1636360	+	858	WP_206841143.1	DUF4868 domain-containing protein	-
CFI10_RS07885	1636525..1636839	+	315	WP_206841144.1	transcriptional regulator	-
CFI10_RS07890	1636832..1637131	+	300	WP_206841145.1	helix-turn-helix domain-containing protein	-
CFI10_RS07895	1637176..1637394	-	219	WP_206842033.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
CFI10_RS07900	1637464..1637718	+	255	WP_206841146.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CFI10_RS07905	1637711..1637974	+	264	WP_206841147.1	Txe/YoeB family addiction module toxin	Toxin
CFI10_RS07910	1638214..1639545	+	1332	WP_206841148.1	30S ribosomal protein S12 methylthiotransferase RimO	-
CFI10_RS07915	1639649..1640812	+	1164	WP_206841149.1	EAL domain-containing protein	-
CFI10_RS07920	1640795..1641076	-	282	WP_091826927.1	YfcL family protein	-
CFI10_RS07925	1641073..1641783	-	711	WP_091826928.1	DUF3108 domain-containing protein	-
CFI10_RS07930	1641798..1642445	-	648	WP_206841150.1	phosphoribosylglycinamide formyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1625570..1637974	12404
	-	flank	IS/Tn	-	-	1633071..1634375	1304

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10417.81 Da
• Isoelectric Point: 9.4079

>T78859 WP_206841147.1 NZ_CP022297:1637711-1637974 [Marinobacterium georgiense]
MSSRLLSWTDESWSDYLYWQTQDKKTLKRINKLISDVRRSPFEGIGKPEQLKENLAGFWSRRIDDTNRLVYAVDDKAITI
ISCRYHY

Nucleotide

• Length: 264 bp

>T78859 NZ_CP022297:1637711-1637974 [Marinobacterium georgiense]
ATGAGTAGTCGTTTACTGTCATGGACTGACGAATCCTGGAGCGATTACCTTTATTGGCAAACCCAGGACAAAAAAACGCT
CAAACGAATAAACAAGCTTATAAGCGATGTCAGGCGCTCACCGTTTGAAGGTATTGGTAAGCCAGAGCAGCTAAAGGAGA
ACTTGGCTGGTTTTTGGTCCCGACGAATAGATGATACGAATCGATTGGTCTACGCAGTTGATGATAAAGCGATTACGATC
ATCTCGTGTCGTTACCACTATTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9456.66 Da
• Isoelectric Point: 4.7639

>AT78859 WP_206841146.1 NZ_CP022297:1637464-1637718 [Marinobacterium georgiense]
MRIVSFTEARNSLKAVLDSVVNDADTAIITRRDSEDAVVMSLDYYNSLMETVHLLRSPANADHLNRSIEQFKAGKVTCRD
LIDE

Nucleotide

• Length: 255 bp

>AT78859 NZ_CP022297:1637464-1637718 [Marinobacterium georgiense]
ATGAGAATTGTGTCTTTTACGGAAGCAAGAAATAGTCTGAAAGCGGTTTTGGATTCCGTCGTTAATGACGCAGATACAGC
AATCATTACTCGCCGTGATTCGGAAGATGCTGTTGTTATGTCGTTAGACTACTACAACAGTCTGATGGAAACGGTGCACT
TGCTGCGTTCACCTGCAAATGCTGACCATTTGAATCGCTCAATCGAACAATTCAAAGCAGGCAAGGTAACCTGCAGAGAC
TTGATTGATGAGTAG