Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 4004197..4004828 Replicon chromosome
Accession NZ_CP022296
Organism Nocardioides sp. S5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CFI00_RS19790 Protein ID WP_207082685.1
Coordinates 4004197..4004541 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CFI00_RS19795 Protein ID WP_207082686.1
Coordinates 4004583..4004828 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFI00_RS19765 3999242..4000417 - 1176 WP_207082680.1 ABC transporter permease -
CFI00_RS19770 4000427..4001368 - 942 WP_207082681.1 ATP-binding cassette domain-containing protein -
CFI00_RS19775 4001526..4001714 + 189 WP_207082682.1 hypothetical protein -
CFI00_RS19780 4001826..4003013 + 1188 WP_207082683.1 alcohol dehydrogenase catalytic domain-containing protein -
CFI00_RS19785 4003050..4004174 - 1125 WP_207082684.1 serine hydrolase -
CFI00_RS19790 4004197..4004541 - 345 WP_207082685.1 PIN domain-containing protein Toxin
CFI00_RS19795 4004583..4004828 - 246 WP_207082686.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CFI00_RS19800 4004869..4006035 - 1167 WP_207082687.1 hypothetical protein -
CFI00_RS19805 4006156..4006563 + 408 WP_207082688.1 hypothetical protein -
CFI00_RS19810 4006594..4007160 + 567 WP_207082689.1 hypothetical protein -
CFI00_RS19815 4007157..4007804 + 648 WP_207082690.1 nucleoside/nucleotide kinase family protein -
CFI00_RS19820 4007957..4009273 + 1317 WP_207082691.1 hypothetical protein -
CFI00_RS19825 4009270..4009605 + 336 WP_207082692.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(11-103)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-48)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12201.11 Da        Isoelectric Point: 4.0944

>T78857 WP_207082685.1 NZ_CP022296:c4004541-4004197 [Nocardioides sp. S5]
VAEAESDALVVELRSEQSTLVACLLLETELRRVVAREPALSQQVVTQLLRGVDLYDLPPPLFAQAGLLPGTDLRSLDALH
LAAAIRLEVEAVITYDARMAEAATLLGLDVLAPS

Download         Length: 345 bp

>T78857 NZ_CP022296:c4004541-4004197 [Nocardioides sp. S5]
GTGGCCGAAGCAGAGTCGGACGCGCTGGTGGTCGAGCTCCGTAGCGAACAATCCACCTTGGTGGCATGCCTGCTGCTGGA
GACGGAGCTGCGTCGCGTCGTGGCACGCGAGCCTGCCCTGTCCCAGCAGGTCGTCACCCAGCTGCTGCGCGGCGTGGACC
TCTACGACCTGCCGCCGCCCCTCTTCGCCCAGGCCGGCCTGCTTCCGGGGACTGACCTCCGATCGCTGGACGCCCTCCAC
CTGGCCGCCGCGATCCGGCTCGAGGTCGAGGCGGTCATCACCTACGACGCGCGCATGGCCGAGGCGGCGACGTTGCTGGG
TCTCGACGTCCTCGCCCCGTCCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8993.17 Da        Isoelectric Point: 9.4464

>AT78857 WP_207082686.1 NZ_CP022296:c4004828-4004583 [Nocardioides sp. S5]
VRTISQRELRNDNAAIIRAVEEGESFTVTRRGVPIARLTPVPESDLRRVRAAAPENDVTALPRVAALRPIADHLDDLRGD
R

Download         Length: 246 bp

>AT78857 NZ_CP022296:c4004828-4004583 [Nocardioides sp. S5]
GTGAGGACGATCAGCCAGCGCGAGCTCCGCAACGACAACGCGGCGATCATCCGCGCCGTCGAGGAGGGGGAGTCCTTCAC
GGTGACCAGACGCGGGGTTCCCATCGCGCGACTGACGCCCGTCCCGGAATCGGACCTCCGGCGGGTCCGAGCTGCCGCTC
CCGAGAACGACGTCACCGCGCTGCCGCGCGTGGCGGCCCTGCGGCCGATAGCCGACCACCTCGACGACCTCCGGGGAGAC
CGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References