Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1442002..1442565 Replicon chromosome
Accession NZ_CP022296
Organism Nocardioides sp. S5

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CFI00_RS07160 Protein ID WP_207084518.1
Coordinates 1442002..1442274 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CFI00_RS07165 Protein ID WP_179652963.1
Coordinates 1442281..1442565 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFI00_RS07130 1437828..1438325 + 498 WP_207084512.1 nuclear transport factor 2 family protein -
CFI00_RS07135 1438371..1439213 + 843 WP_207084513.1 alpha/beta fold hydrolase -
CFI00_RS07140 1439282..1439620 + 339 WP_207084514.1 Rieske 2Fe-2S domain-containing protein -
CFI00_RS07145 1439620..1440543 + 924 WP_207084515.1 hypothetical protein -
CFI00_RS07150 1440559..1441215 + 657 WP_207084516.1 hypothetical protein -
CFI00_RS07155 1441235..1441360 + 126 WP_207084517.1 hypothetical protein -
CFI00_RS07160 1442002..1442274 - 273 WP_207084518.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFI00_RS07165 1442281..1442565 - 285 WP_179652963.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CFI00_RS07170 1442981..1444159 - 1179 WP_207084519.1 IS481 family transposase -
CFI00_RS07175 1444538..1445443 + 906 WP_207084520.1 helix-turn-helix domain-containing protein -
CFI00_RS07180 1445453..1446316 - 864 WP_207084521.1 alpha/beta fold hydrolase -
CFI00_RS07185 1446351..1446692 - 342 WP_207084522.1 DUF2200 family protein -
CFI00_RS07190 1446726..1447319 - 594 WP_207084523.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1298325..1444236 145911


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10585.22 Da        Isoelectric Point: 10.4723

>T78855 WP_207084518.1 NZ_CP022296:c1442274-1442002 [Nocardioides sp. S5]
VSQAYEVRLASPARRDLRRVPPRIVPAIVEFLYGELARNPKRVGKALERELEGYWSARRGPYRIIYRIDDDQLIVLVVNV
DHRADVYRPR

Download         Length: 273 bp

>T78855 NZ_CP022296:c1442274-1442002 [Nocardioides sp. S5]
GTGAGCCAGGCCTACGAGGTCCGCCTCGCCTCGCCGGCGCGACGCGACCTGCGCAGGGTGCCGCCGCGCATCGTACCTGC
GATCGTGGAGTTCCTTTACGGCGAGCTCGCGCGGAACCCTAAGCGCGTCGGCAAGGCGCTCGAGCGTGAGCTTGAGGGCT
ACTGGTCGGCCCGGCGTGGCCCATACCGGATCATCTATCGTATCGACGACGACCAGCTCATCGTGCTGGTCGTCAACGTC
GACCACCGCGCGGACGTGTACCGCCCGCGCTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10691.03 Da        Isoelectric Point: 4.4777

>AT78855 WP_179652963.1 NZ_CP022296:c1442565-1442281 [Nocardioides sp. S5]
MQTLPISKVKDKLNEFVEAVSLTREQVTITKNGSPAAVLVGADEWESLQETLFWLSRPKTLDDIAEAEREYAEGKTIRED
EIRSEFNVPRRPTA

Download         Length: 285 bp

>AT78855 NZ_CP022296:c1442565-1442281 [Nocardioides sp. S5]
ATGCAGACGCTACCGATCTCAAAGGTCAAGGACAAGCTCAACGAGTTCGTCGAGGCCGTCTCGTTGACCCGTGAGCAGGT
CACGATCACCAAGAACGGCTCGCCCGCCGCGGTGCTCGTCGGCGCCGACGAGTGGGAGTCGCTCCAGGAAACCCTGTTCT
GGCTCTCGCGCCCAAAGACCCTCGACGACATCGCCGAGGCCGAGCGTGAGTACGCTGAAGGCAAGACGATCCGCGAGGAC
GAGATCCGCTCCGAGTTCAACGTTCCGCGCCGCCCCACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References