Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2075318..2075847 Replicon chromosome
Accession NZ_CP022291
Organism Staphylococcus aureus strain EDCC5464

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CFN13_RS10570 Protein ID WP_000621175.1
Coordinates 2075318..2075680 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CFN13_RS10575 Protein ID WP_000948330.1
Coordinates 2075677..2075847 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFN13_RS10545 2072297..2073067 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
CFN13_RS10550 2073042..2073521 - 480 WP_001190825.1 anti-sigma B factor RsbW -
CFN13_RS10555 2073523..2073849 - 327 WP_001052491.1 anti-sigma factor antagonist -
CFN13_RS10560 2073968..2074969 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
CFN13_RS10570 2075318..2075680 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CFN13_RS10575 2075677..2075847 - 171 WP_000948330.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
CFN13_RS10580 2075932..2077080 - 1149 WP_001281141.1 alanine racemase -
CFN13_RS10585 2077146..2077505 - 360 WP_000581193.1 holo-ACP synthase -
CFN13_RS10590 2077509..2078000 - 492 WP_001205918.1 PH domain-containing protein -
CFN13_RS10595 2077987..2079570 - 1584 WP_001294624.1 PH domain-containing protein -
CFN13_RS10600 2079563..2080042 - 480 WP_001287080.1 hypothetical protein -
CFN13_RS10605 2080251..2080811 - 561 WP_001092400.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T78846 WP_000621175.1 NZ_CP022291:c2075680-2075318 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T78846 NZ_CP022291:c2075680-2075318 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATTATTCAAAATGACACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAATATAAATTGGATAAAGACTCAGTCATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTATTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6237.75 Da        Isoelectric Point: 3.8305

>AT78846 WP_000948330.1 NZ_CP022291:c2075847-2075677 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNESYLSSNSTNE

Download         Length: 171 bp

>AT78846 NZ_CP022291:c2075847-2075677 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAATCATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References