Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 803717..804194 Replicon chromosome
Accession NZ_CP022291
Organism Staphylococcus aureus strain EDCC5464

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CFN13_RS03905 Protein ID WP_000052076.1
Coordinates 803717..803905 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CFN13_RS03910 Protein ID WP_001059690.1
Coordinates 803934..804194 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFN13_RS03875 799707..800228 + 522 WP_000824488.1 hypothetical protein -
CFN13_RS03880 800569..801255 + 687 WP_001670297.1 thermonuclease family protein -
CFN13_RS03885 801612..801812 + 201 WP_001059082.1 cold-shock protein -
CFN13_RS03890 802308..802526 - 219 WP_000005876.1 hypothetical protein -
CFN13_RS03895 802588..802872 - 285 WP_001004395.1 hypothetical protein -
CFN13_RS03900 802960..803529 - 570 WP_001106646.1 hypothetical protein -
CFN13_RS03905 803717..803905 - 189 WP_000052076.1 hypothetical protein Toxin
CFN13_RS03910 803934..804194 - 261 WP_001059690.1 hypothetical protein Antitoxin
CFN13_RS03915 804534..804737 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CFN13_RS03920 804734..804970 - 237 WP_000368687.1 hypothetical protein -
CFN13_RS03925 805195..805776 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
CFN13_RS03930 805849..806466 - 618 WP_000255559.1 LysE/ArgO family amino acid transporter -
CFN13_RS03935 806620..807114 - 495 WP_000590539.1 GNAT family N-acetyltransferase -
CFN13_RS03940 807513..807935 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
CFN13_RS03945 808083..808799 + 717 WP_000150015.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T78839 WP_000052076.1 NZ_CP022291:c803905-803717 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T78839 NZ_CP022291:c803905-803717 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTTACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT78839 WP_001059690.1 NZ_CP022291:c804194-803934 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT78839 NZ_CP022291:c804194-803934 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References