78823

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 818327..818804 Replicon chromosome
Accession NZ_CP022290
Organism Staphylococcus aureus strain EDCC5458

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag CFN12_RS04100 Protein ID WP_000052078.1
Coordinates 818327..818515 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CFN12_RS04105 Protein ID WP_001059690.1
Coordinates 818544..818804 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFN12_RS04070 814368..814838 + 471 WP_000824472.1 hypothetical protein -
CFN12_RS04075 815179..815865 + 687 WP_001548082.1 thermonuclease family protein -
CFN12_RS04080 816222..816422 + 201 WP_001059082.1 cold-shock protein -
CFN12_RS04085 816918..817136 - 219 WP_000005886.1 hypothetical protein -
CFN12_RS04090 817198..817482 - 285 WP_001004395.1 hypothetical protein -
CFN12_RS04095 817570..818139 - 570 WP_001106654.1 hypothetical protein -
CFN12_RS04100 818327..818515 - 189 WP_000052078.1 hypothetical protein Toxin
CFN12_RS04105 818544..818804 - 261 WP_001059690.1 hypothetical protein Antitoxin
CFN12_RS04110 819145..819348 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CFN12_RS04115 819345..819581 - 237 WP_000368687.1 hypothetical protein -
CFN12_RS04120 819806..820387 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
CFN12_RS04125 820460..821077 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
CFN12_RS04130 821232..821726 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CFN12_RS04135 822125..822547 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CFN12_RS04140 822695..823411 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T78823 WP_000052078.1 NZ_CP022290:c818515-818327 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T78823 NZ_CP022290:c818515-818327 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT78823 WP_001059690.1 NZ_CP022290:c818804-818544 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT78823 NZ_CP022290:c818804-818544 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References