Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1510707..1511386 Replicon chromosome
Accession NZ_CP022283
Organism Acinetobacter baumannii strain 7804

Toxin (Protein)


Gene name hicA Uniprot ID A0A2S4SYJ5
Locus tag Aba7804_RS07325 Protein ID WP_002108505.1
Coordinates 1510707..1510889 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag Aba7804_RS07330 Protein ID WP_000966688.1
Coordinates 1510982..1511386 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Aba7804_RS07280 1505781..1506149 + 369 WP_002154735.1 hypothetical protein -
Aba7804_RS07285 1506151..1506549 + 399 WP_001251837.1 hypothetical protein -
Aba7804_RS07290 1506551..1506769 + 219 WP_001277696.1 hypothetical protein -
Aba7804_RS07295 1506878..1507399 + 522 WP_000749906.1 SH3 domain-containing protein -
Aba7804_RS07300 1507496..1507849 + 354 WP_117345760.1 hypothetical protein -
Aba7804_RS07305 1507849..1508826 + 978 WP_117345761.1 phage tail protein -
Aba7804_RS07310 1508879..1509796 + 918 WP_000094250.1 hypothetical protein -
Aba7804_RS07315 1509866..1510381 + 516 WP_117345762.1 hypothetical protein -
Aba7804_RS07325 1510707..1510889 + 183 WP_002108505.1 type II toxin-antitoxin system HicA family toxin Toxin
Aba7804_RS07330 1510982..1511386 + 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Aba7804_RS07335 1511485..1511661 + 177 WP_075149899.1 hypothetical protein -
Aba7804_RS07340 1511670..1511993 + 324 WP_000523928.1 DUF4236 domain-containing protein -
Aba7804_RS07345 1512026..1512409 + 384 WP_000725050.1 hypothetical protein -
Aba7804_RS07350 1512471..1513217 + 747 WP_000599536.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1477637..1527249 49612


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6685.80 Da        Isoelectric Point: 10.5523

>T78818 WP_002108505.1 NZ_CP022283:1510707-1510889 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTISHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T78818 NZ_CP022283:1510707-1510889 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAAGGGTTAGTTACAATCTCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT78818 WP_000966688.1 NZ_CP022283:1510982-1511386 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT78818 NZ_CP022283:1510982-1511386 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4SYJ5

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References