Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 748547..749200 Replicon chromosome
Accession NZ_CP022283
Organism Acinetobacter baumannii strain 7804

Toxin (Protein)


Gene name cptA Uniprot ID A0A3R9G864
Locus tag Aba7804_RS03650 Protein ID WP_000607075.1
Coordinates 748811..749200 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag Aba7804_RS03645 Protein ID WP_001288210.1
Coordinates 748547..748804 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Aba7804_RS03625 744064..745071 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
Aba7804_RS03630 745090..745467 + 378 WP_001216380.1 50S ribosomal protein L17 -
Aba7804_RS03635 745649..747139 + 1491 WP_000415123.1 NAD(P)/FAD-dependent oxidoreductase -
Aba7804_RS03640 747188..748359 - 1172 Protein_697 acyl-CoA dehydrogenase family protein -
Aba7804_RS03645 748547..748804 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
Aba7804_RS03650 748811..749200 + 390 WP_000607075.1 membrane protein Toxin
Aba7804_RS03655 749970..751055 + 1086 WP_117345721.1 hypothetical protein -
Aba7804_RS03660 751133..751699 + 567 WP_000651534.1 rhombosortase -
Aba7804_RS03665 751887..754082 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.94 Da        Isoelectric Point: 10.3890

>T78817 WP_000607075.1 NZ_CP022283:748811-749200 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLVEWKKLKTLEKLY

Download         Length: 390 bp

>T78817 NZ_CP022283:748811-749200 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGTAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT78817 WP_001288210.1 NZ_CP022283:748547-748804 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT78817 NZ_CP022283:748547-748804 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9G864

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References