Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1572142..1572837 Replicon chromosome
Accession NZ_CP022278
Organism Neisseria chenwenguii strain 10023

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BG910_RS07760 Protein ID WP_089037190.1
Coordinates 1572142..1572324 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BG910_RS07765 Protein ID WP_089036346.1
Coordinates 1572433..1572837 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG910_RS12320 1567586..1567891 - 306 WP_123805964.1 hypothetical protein -
BG910_RS12325 1567952..1568302 - 351 WP_123805963.1 hypothetical protein -
BG910_RS07745 1568474..1569565 - 1092 WP_089036344.1 redox-regulated ATPase YchF -
BG910_RS07750 1569677..1570108 - 432 WP_089037189.1 EamA family transporter -
BG910_RS07755 1570268..1571944 + 1677 WP_089036345.1 formate--tetrahydrofolate ligase -
BG910_RS07760 1572142..1572324 + 183 WP_089037190.1 type II toxin-antitoxin system HicA family toxin Toxin
BG910_RS07765 1572433..1572837 + 405 WP_089036346.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BG910_RS07770 1572921..1573472 + 552 WP_089036347.1 oligoribonuclease -
BG910_RS07775 1574085..1575182 + 1098 WP_089036348.1 porin -
BG910_RS07780 1575337..1577319 - 1983 WP_089036349.1 DNA topoisomerase IV subunit B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6773.83 Da        Isoelectric Point: 9.9765

>T78777 WP_089037190.1 NZ_CP022278:1572142-1572324 [Neisseria chenwenguii]
MTSSEVIKLLEADGWYCVATQDSHWQYKHPDKKGRVTVPHPKKDLPKGTINSILKQAGIK

Download         Length: 183 bp

>T78777 NZ_CP022278:1572142-1572324 [Neisseria chenwenguii]
ATGACGAGCAGTGAAGTCATTAAGCTGCTTGAAGCCGACGGATGGTATTGTGTTGCCACCCAAGACAGCCACTGGCAGTA
CAAACACCCTGATAAAAAAGGCCGTGTAACGGTACCCCATCCTAAAAAAGACTTGCCGAAAGGTACTATCAACAGCATTT
TGAAGCAGGCGGGCATCAAGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14947.61 Da        Isoelectric Point: 4.4169

>AT78777 WP_089036346.1 NZ_CP022278:1572433-1572837 [Neisseria chenwenguii]
MFIPVAIHKDEESIFGVSVPDLPGCFSYGETEEEALHNTRQAVVFHVEGMLADGEFDSLTPSRIADLQESGDYDGATWAL
VDVDLSKISNKQTRFNVSWPEYLLRRVDAYAAAHHETRSGFLAKAAQQMLQQQS

Download         Length: 405 bp

>AT78777 NZ_CP022278:1572433-1572837 [Neisseria chenwenguii]
ATGTTTATTCCGGTTGCCATTCATAAAGATGAAGAATCGATATTTGGTGTATCCGTACCTGATCTTCCGGGCTGTTTTTC
ATACGGTGAAACAGAGGAAGAAGCCTTGCATAATACCCGACAAGCTGTAGTATTTCATGTTGAGGGTATGTTGGCAGATG
GTGAATTCGACAGCTTGACCCCCAGTAGAATTGCCGATTTGCAGGAATCTGGTGATTACGATGGTGCAACCTGGGCTTTG
GTTGACGTGGATTTGAGCAAAATCAGCAACAAGCAAACCCGCTTCAATGTGAGCTGGCCAGAATATCTGTTGCGCCGAGT
GGATGCCTATGCCGCCGCTCATCATGAAACCCGTTCCGGTTTCTTGGCCAAAGCCGCACAGCAGATGTTGCAACAGCAAT
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References