Detailed information of TA system TA078770

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1311972..1312630
• Replicon: chromosome
• Accession: NZ_CP022278
• Organism: Neisseria chenwenguii strain 10023

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BG910_RS06475
• Protein ID: WP_089036137.1
• Coordinates: 1311972..1312373 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: -
• Locus tag: BG910_RS06480
• Protein ID: WP_089036138.1
• Coordinates: 1312370..1312630 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BG910_RS06445	1307378..1307911	-	534	WP_089037172.1	conjugal transfer protein TrbM	-
BG910_RS12560	1308038..1308214	-	177	WP_198344762.1	hypothetical protein	-
BG910_RS12270	1308233..1308370	-	138	WP_157694023.1	hypothetical protein	-
BG910_RS06455	1308454..1308822	-	369	WP_089037173.1	hypothetical protein	-
BG910_RS06460	1308828..1309334	-	507	WP_089035847.1	hypothetical protein	-
BG910_RS06465	1310109..1310735	+	627	WP_089036135.1	hypothetical protein	-
BG910_RS06470	1310721..1310969	-	249	WP_157694042.1	hypothetical protein	-
BG910_RS06475	1311972..1312373	-	402	WP_089036137.1	type II toxin-antitoxin system VapC family toxin	Toxin
BG910_RS06480	1312370..1312630	-	261	WP_089036138.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
BG910_RS06485	1312743..1313342	-	600	WP_089036139.1	LexA family transcriptional regulator	-
BG910_RS06490	1313468..1313677	+	210	WP_089036140.1	helix-turn-helix domain-containing protein	-
BG910_RS06495	1313684..1314484	+	801	WP_089036141.1	hypothetical protein	-
BG910_RS06500	1314966..1315253	+	288	WP_089036142.1	ribbon-helix-helix domain-containing protein	-
BG910_RS06505	1315241..1315540	+	300	WP_089036143.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BG910_RS06510	1315587..1315973	-	387	WP_089036144.1	type II toxin-antitoxin system VapC family toxin	-
BG910_RS06515	1315970..1316215	-	246	WP_089036145.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
BG910_RS06520	1316310..1316744	-	435	WP_157694043.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14440.71 Da
• Isoelectric Point: 6.8707

>T78770 WP_089036137.1 NZ_CP022278:c1312373-1311972 [Neisseria chenwenguii]
MKRFLLDTNIVSHAVRGNEAVLKHLAATPMSALCISAVTHAEMMYGLAKRPEALRLRRLVNEFLLRVEVLPFDSAVAEDY
GTFRAVIESAGRSLSPPDMQIAAHAYSIGAVLVSNDRAFSAIAGLETVDWLGS

Nucleotide

• Length: 402 bp

>T78770 NZ_CP022278:c1312373-1311972 [Neisseria chenwenguii]
ATGAAACGTTTTTTGTTGGATACCAACATCGTCAGTCATGCGGTGCGTGGTAATGAAGCGGTTTTAAAACATCTGGCAGC
TACGCCTATGTCGGCATTATGTATTTCTGCCGTTACCCATGCCGAGATGATGTATGGTTTAGCCAAACGTCCCGAGGCAT
TACGTTTGCGCCGTTTGGTAAATGAGTTTTTGCTGAGGGTGGAAGTTTTACCTTTTGATAGTGCGGTGGCAGAGGATTAC
GGCACGTTTCGTGCGGTAATCGAAAGTGCAGGGCGCAGCTTATCTCCGCCCGATATGCAGATTGCCGCACATGCTTACAG
TATCGGGGCTGTTTTGGTCAGCAATGACCGGGCTTTCTCTGCAATTGCAGGATTGGAAACAGTTGATTGGCTGGGTAGTT
AA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9846.98 Da
• Isoelectric Point: 5.1425

>AT78770 WP_089036138.1 NZ_CP022278:c1312630-1312370 [Neisseria chenwenguii]
MQTAKIFNNGNSQAVRLPLAFRFEGNEVFIRRDEKTGDVVLSKRPADWEGFIHALGNKETIPSEPFARTENDKAPVQRDP
FEGWQE

Nucleotide

• Length: 261 bp

>AT78770 NZ_CP022278:c1312630-1312370 [Neisseria chenwenguii]
ATGCAAACTGCCAAAATATTCAACAACGGCAACAGTCAGGCCGTGCGCCTGCCTTTGGCATTCCGTTTTGAAGGCAATGA
GGTTTTTATACGCCGTGATGAGAAAACCGGTGATGTTGTTCTGTCCAAACGCCCTGCGGATTGGGAAGGCTTTATCCATG
CGCTTGGAAACAAAGAGACTATTCCGTCAGAGCCGTTTGCCCGTACTGAAAACGACAAAGCTCCCGTTCAGCGCGATCCT
TTTGAAGGATGGCAGGAATGA