Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1130945..1131531 Replicon chromosome
Accession NZ_CP022278
Organism Neisseria chenwenguii strain 10023

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BG910_RS05585 Protein ID WP_089035989.1
Coordinates 1130945..1131199 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BG910_RS05590 Protein ID WP_089035990.1
Coordinates 1131196..1131531 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG910_RS05565 1126421..1127344 - 924 WP_089035986.1 hypothetical protein -
BG910_RS05570 1127668..1128591 - 924 WP_089035987.1 hypothetical protein -
BG910_RS05575 1129093..1129413 + 321 WP_123805279.1 hypothetical protein -
BG910_RS05580 1129469..1130860 + 1392 WP_089037154.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
BG910_RS05585 1130945..1131199 + 255 WP_089035989.1 type II toxin-antitoxin system HicA family toxin Toxin
BG910_RS05590 1131196..1131531 + 336 WP_089035990.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BG910_RS05595 1131648..1133789 + 2142 WP_089037155.1 TIGR01666 family membrane protein -
BG910_RS05600 1133900..1134790 + 891 WP_089035991.1 ABC transporter ATP-binding protein -
BG910_RS05605 1134889..1135125 - 237 WP_089035992.1 hypothetical protein -
BG910_RS05610 1135665..1135901 - 237 WP_089035993.1 hypothetical protein -
BG910_RS05615 1135984..1136241 - 258 WP_089035994.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9199.64 Da        Isoelectric Point: 10.5597

>T78769 WP_089035989.1 NZ_CP022278:1130945-1131199 [Neisseria chenwenguii]
MKKKHQRTLSLIYARPIPGSIKWADIEALFNELGGEIEARAGSRVAVILFGQVQVFHRPHPGPDTDKGAVAAVRKWLEAN
GVSP

Download         Length: 255 bp

>T78769 NZ_CP022278:1130945-1131199 [Neisseria chenwenguii]
ATGAAGAAAAAGCACCAGCGTACACTAAGCCTGATTTATGCCCGCCCTATACCCGGCAGCATCAAATGGGCGGACATCGA
AGCCTTGTTTAACGAACTTGGCGGCGAAATCGAAGCACGGGCGGGAAGCCGTGTGGCGGTTATCCTGTTCGGACAGGTTC
AGGTTTTCCACCGCCCGCACCCTGGCCCCGATACAGACAAGGGCGCGGTGGCGGCGGTCAGGAAATGGCTGGAAGCAAAC
GGAGTAAGCCCATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12113.60 Da        Isoelectric Point: 6.8683

>AT78769 WP_089035990.1 NZ_CP022278:1131196-1131531 [Neisseria chenwenguii]
MNNIMNINGHKALIQYDPETELLRGEFIGLNGGADFYADNVADLHKEGAVSLQTYLDVCRERGIGPYKHYSGRFNVRISP
QIHAAAAAAAAASNISLNEWVAQTLNRAVRG

Download         Length: 336 bp

>AT78769 NZ_CP022278:1131196-1131531 [Neisseria chenwenguii]
ATGAACAACATCATGAACATCAACGGGCATAAAGCCCTGATTCAATACGATCCCGAAACCGAGCTTTTGCGCGGGGAATT
TATCGGCCTGAACGGCGGTGCGGATTTTTATGCCGATAATGTGGCCGACCTGCATAAAGAGGGGGCGGTCAGCCTGCAAA
CCTATTTGGACGTTTGCAGGGAACGCGGAATCGGGCCGTACAAACATTATTCGGGACGGTTTAATGTCCGAATCAGCCCG
CAGATTCATGCCGCCGCCGCTGCGGCTGCCGCTGCGAGCAACATCAGTCTGAACGAATGGGTTGCGCAGACGCTGAATCG
GGCTGTCCGCGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References