Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4075929..4076583 Replicon chromosome
Accession NZ_CP022273
Organism Citrobacter freundii strain 18-1

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag CFA70_RS20995 Protein ID WP_003026936.1
Coordinates 4076176..4076583 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag CFA70_RS20990 Protein ID WP_003026938.1
Coordinates 4075929..4076195 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFA70_RS20960 4071130..4072563 - 1434 WP_088903082.1 6-phospho-beta-glucosidase BglA -
CFA70_RS20965 4072684..4073412 - 729 WP_060855085.1 MurR/RpiR family transcriptional regulator -
CFA70_RS20970 4073465..4073776 + 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
CFA70_RS20975 4073939..4074598 + 660 WP_003838267.1 hemolysin III family protein -
CFA70_RS20980 4074692..4075672 - 981 WP_088903083.1 tRNA-modifying protein YgfZ -
CFA70_RS20990 4075929..4076195 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
CFA70_RS20995 4076176..4076583 + 408 WP_003026936.1 protein YgfX Toxin
CFA70_RS21000 4076628..4077149 - 522 WP_003026933.1 flavodoxin FldB -
CFA70_RS21005 4077263..4078159 + 897 WP_088903084.1 site-specific tyrosine recombinase XerD -
CFA70_RS21010 4078183..4078896 + 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CFA70_RS21015 4078902..4080635 + 1734 WP_048232743.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T78760 WP_003026936.1 NZ_CP022273:4076176-4076583 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T78760 NZ_CP022273:4076176-4076583 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTGTTGATGGATGGACGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCAGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAAC
AGAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT78760 WP_003026938.1 NZ_CP022273:4075929-4076195 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT78760 NZ_CP022273:4075929-4076195 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References