Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 59527..60068 Replicon plasmid plA
Accession NZ_CP022264
Organism Xanthomonas citri pv. vignicola strain CFBP7111

Toxin (Protein)


Gene name mazF Uniprot ID A0A220WPB1
Locus tag XcvCFBP7111P_RS24810 Protein ID WP_005917856.1
Coordinates 59527..59850 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A220WPJ3
Locus tag XcvCFBP7111P_RS24815 Protein ID WP_005917854.1
Coordinates 59847..60068 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XcvCFBP7111P_RS24795 57550..57834 + 285 WP_003490829.1 hypothetical protein -
XcvCFBP7111P_RS24800 58020..59207 - 1188 WP_029220895.1 zeta toxin family protein -
XcvCFBP7111P_RS24805 59214..59501 - 288 WP_029220894.1 hypothetical protein -
XcvCFBP7111P_RS24810 59527..59850 - 324 WP_005917856.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
XcvCFBP7111P_RS24815 59847..60068 - 222 WP_005917854.1 antitoxin MazE family protein Antitoxin
XcvCFBP7111P_RS24820 60266..60832 + 567 WP_046932484.1 recombinase family protein -
XcvCFBP7111P_RS24825 61061..61711 + 651 WP_089113699.1 recombinase family protein -
XcvCFBP7111P_RS24830 61786..62139 + 354 WP_089113700.1 hypothetical protein -
XcvCFBP7111P_RS24840 63045..64189 + 1145 WP_089111531.1 IS3 family transposase -
XcvCFBP7111P_RS24855 64731..65042 - 312 WP_089113702.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..148077 148077


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(9-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11513.56 Da        Isoelectric Point: 6.2913

>T78737 WP_005917856.1 NZ_CP022264:c59850-59527 [Xanthomonas citri pv. vignicola]
MTQRGDLVTVALPGAYGKPRPALVIQSDLLAELESVLVCPITSDLRDAMFRVTVEPSLTNGLQKISQVMVDKTAPIPRAK
VSEPIGTLDAERMRAVERALMLVTGLA

Download         Length: 324 bp

>T78737 NZ_CP022264:c59850-59527 [Xanthomonas citri pv. vignicola]
ATGACGCAGCGTGGCGACTTGGTAACGGTGGCTTTGCCGGGAGCCTACGGCAAGCCACGGCCGGCGCTAGTCATCCAGTC
CGATTTGCTTGCCGAGCTGGAAAGCGTCCTCGTATGCCCGATCACAAGCGATCTGCGCGACGCGATGTTTCGGGTCACGG
TCGAGCCGAGTCTGACCAATGGTCTACAGAAGATTTCGCAGGTCATGGTGGACAAGACAGCACCGATACCTCGCGCGAAA
GTCAGTGAGCCGATTGGCACGCTCGACGCAGAACGCATGAGGGCCGTCGAACGCGCCCTCATGCTCGTCACCGGGCTGGC
ATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8240.23 Da        Isoelectric Point: 8.1023

>AT78737 WP_005917854.1 NZ_CP022264:c60068-59847 [Xanthomonas citri pv. vignicola]
MPRTHNPTNKVTRHRDRLRAAGYRPVQFWVHDTRSPELAAMLSRQCRSLHGDPTETDAIGFGEAAAGLIEGWE

Download         Length: 222 bp

>AT78737 NZ_CP022264:c60068-59847 [Xanthomonas citri pv. vignicola]
ATGCCGAGAACTCACAATCCGACGAACAAGGTCACCCGTCATCGTGACCGACTGCGTGCAGCCGGGTACAGGCCAGTGCA
GTTTTGGGTGCACGATACCCGCTCGCCCGAGTTGGCTGCGATGCTCAGCCGCCAGTGTCGCAGCCTGCATGGTGATCCAA
CCGAAACCGATGCTATCGGCTTCGGTGAAGCCGCCGCTGGCCTTATCGAGGGGTGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A220WPB1

Antitoxin

Source ID Structure
AlphaFold DB A0A220WPJ3

References