Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-doc
Location 13660..14243 Replicon plasmid pAMT1
Accession NZ_CP022249
Organism Staphylococcus epidermidis strain AMT

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag CFE88_RS12410 Protein ID WP_058703189.1
Coordinates 13905..14243 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag CFE88_RS12405 Protein ID WP_088922895.1
Coordinates 13660..13908 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFE88_RS12370 9298..9885 + 588 WP_088922898.1 hypothetical protein -
CFE88_RS12375 10227..10760 + 534 WP_002477877.1 DUF536 domain-containing protein -
CFE88_RS12380 10760..11533 + 774 WP_088922897.1 hypothetical protein -
CFE88_RS12385 11773..12039 - 267 WP_002477879.1 Txe/YoeB family addiction module toxin -
CFE88_RS12390 12039..12290 - 252 WP_002477880.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CFE88_RS12395 12308..12514 - 207 WP_002477881.1 hypothetical protein -
CFE88_RS12400 12766..13311 + 546 WP_088922896.1 hypothetical protein -
CFE88_RS12405 13660..13908 + 249 WP_088922895.1 AbrB family transcriptional regulator Antitoxin
CFE88_RS12410 13905..14243 + 339 WP_058703189.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CFE88_RS12415 14777..15154 + 378 WP_088922894.1 hypothetical protein -
CFE88_RS12420 15452..17578 + 2127 WP_088922899.1 hypothetical protein -
CFE88_RS12425 18551..18907 + 357 WP_088922900.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..37770 37770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13106.20 Da        Isoelectric Point: 9.6404

>T78734 WP_058703189.1 NZ_CP022249:13905-14243 [Staphylococcus epidermidis]
MSIKQFDIYYIDLDPTRGREKQKIRPCLIVNNKMTIDGTNFVWALPITNREKRYPLDIEVKTKKGLVTGVIDTLQIRALD
LNEREHNYKDELQDNLKNVVLQAIKTYLKPSS

Download         Length: 339 bp

>T78734 NZ_CP022249:13905-14243 [Staphylococcus epidermidis]
ATGAGCATCAAACAGTTTGATATATACTATATTGACCTAGACCCCACTCGAGGTCGTGAAAAACAAAAAATCAGACCATG
CTTAATCGTAAATAATAAAATGACAATAGATGGTACAAATTTCGTTTGGGCGTTACCAATCACAAATCGCGAGAAACGTT
ATCCATTAGATATCGAAGTGAAAACTAAAAAAGGATTAGTCACAGGTGTTATAGACACGCTTCAGATACGCGCATTAGAC
CTTAATGAACGTGAACATAACTATAAAGATGAATTACAAGACAACTTAAAAAACGTCGTCTTACAAGCAATAAAGACGTA
TTTAAAACCATCATCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9175.33 Da        Isoelectric Point: 4.6802

>AT78734 WP_088922895.1 NZ_CP022249:13660-13908 [Staphylococcus epidermidis]
MIKTSERIFKSGNSKALSLSKQTIQLANFEVGDKVEVSEINGGLFIKKKEESIEDEITNFFKNGGKYTEPEIDFGESVGR
EI

Download         Length: 249 bp

>AT78734 NZ_CP022249:13660-13908 [Staphylococcus epidermidis]
ATGATTAAAACATCTGAACGCATTTTTAAAAGTGGAAACAGCAAAGCACTCAGTTTAAGCAAACAAACAATCCAGTTAGC
TAATTTTGAGGTGGGAGATAAGGTTGAAGTATCTGAAATCAATGGTGGTTTATTTATCAAAAAGAAAGAAGAATCGATTG
AAGATGAAATCACAAACTTTTTCAAAAATGGCGGTAAATACACCGAGCCAGAAATTGATTTTGGAGAGAGTGTAGGTCGT
GAAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References