Detailed information of TA system TA078731

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 396586..397391
• Replicon: chromosome
• Accession: NZ_CP022247
• Organism: Staphylococcus epidermidis strain AMT

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: CFE88_RS02215
• Protein ID: WP_002457885.1
• Coordinates: 397209..397391 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: CFE88_RS02210
• Protein ID: WP_002501163.1
• Coordinates: 396586..397185 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFE88_RS02190	392311..393768	+	1458	WP_088922671.1	ABC transporter substrate-binding protein/permease	-
CFE88_RS02195	393761..394483	+	723	WP_002496430.1	amino acid ABC transporter ATP-binding protein	-
CFE88_RS02200	394831..395961	+	1131	WP_193791304.1	tRNA epoxyqueuosine(34) reductase QueG	-
CFE88_RS02205	395958..396428	+	471	WP_002446764.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
CFE88_RS02210	396586..397185	+	600	WP_002501163.1	glucosamine-6-phosphate isomerase	Antitoxin
CFE88_RS02215	397209..397391	+	183	WP_002457885.1	hypothetical protein	Toxin
CFE88_RS02220	397543..397947	+	405	WP_002446761.1	hypothetical protein	-
CFE88_RS02225	398139..399524	+	1386	WP_002447846.1	class II fumarate hydratase	-
CFE88_RS02230	399999..400481	+	483	Protein_397	transposase	-
CFE88_RS02235	400655..401479	-	825	WP_002446760.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	400170..400481	311

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7080.67 Da
• Isoelectric Point: 4.3016

>T78731 WP_002457885.1 NZ_CP022247:397209-397391 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQPHDNEVRSDFKNSK

Nucleotide

• Length: 183 bp

>T78731 NZ_CP022247:397209-397391 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAACGCTATGGTGACTGATTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAAATTTCACAGGAGAATGATGAAGAAAAATTAAATCAACCTCATGATAACGAAGTTCGTT
CAGATTTTAAAAATAGTAAATAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22665.57 Da
• Isoelectric Point: 4.9942

>AT78731 WP_002501163.1 NZ_CP022247:396586-397185 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHAVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDVSVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT78731 NZ_CP022247:396586-397185 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGACAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTGG
AAAATCATGCAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCAATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAGGGAAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGCAAACTTGACGTTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACCGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAGAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA