Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 245127..245636 Replicon chromosome
Accession NZ_CP022247
Organism Staphylococcus epidermidis strain AMT

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0E1VPY9
Locus tag CFE88_RS01340 Protein ID WP_002447767.1
Coordinates 245427..245636 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A829M395
Locus tag CFE88_RS01335 Protein ID WP_002458700.1
Coordinates 245127..245420 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFE88_RS01310 240134..240922 + 789 WP_002475462.1 hydroxyethylthiazole kinase -
CFE88_RS01315 240928..241566 + 639 WP_002458704.1 thiamine phosphate synthase -
CFE88_RS01320 241655..242527 + 873 WP_002458703.1 membrane protein insertase YidC -
CFE88_RS01325 242634..243287 - 654 WP_002475468.1 HD domain-containing protein -
CFE88_RS01330 243469..244953 - 1485 WP_002447769.1 cardiolipin synthase -
CFE88_RS01335 245127..245420 + 294 WP_002458700.1 copper-sensing transcriptional repressor CsoR Antitoxin
CFE88_RS01340 245427..245636 + 210 WP_002447767.1 cation transporter Toxin
CFE88_RS01345 245780..245917 + 138 WP_001829949.1 hypothetical protein -
CFE88_RS01350 246016..247227 - 1212 WP_002447766.1 rod shape-determining protein RodA -
CFE88_RS01355 247618..248691 + 1074 WP_002458698.1 D-alanine--D-alanine ligase -
CFE88_RS01360 248703..250058 + 1356 WP_002447764.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(10-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 8008.28 Da        Isoelectric Point: 6.4556

>T78729 WP_002447767.1 NZ_CP022247:245427-245636 [Staphylococcus epidermidis]
MKLKKGLIHVSGIKTTEQEKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDCGFRIL

Download         Length: 210 bp

>T78729 NZ_CP022247:245427-245636 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATACATGTTTCAGGTATTAAAACAACTGAACAAGAGAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTGGAATTTGACACTCCCGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTGCGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11082.71 Da        Isoelectric Point: 5.5778

>AT78729 WP_002458700.1 NZ_CP022247:245127-245420 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVAIKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT78729 NZ_CP022247:245127-245420 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATCAATCGTATGATTGATGACGATGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTATTAAATTACTAGATCATCACATGAAGGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VPY9

Antitoxin

Source ID Structure
AlphaFold DB A0A829M395

References