78727

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 2084533..2085080 Replicon chromosome
Accession NZ_CP022243
Organism Vibrio parahaemolyticus strain PB1937

Toxin (Protein)


Gene name relE Uniprot ID A0A7Z2MSV0
Locus tag CFH89_RS10590 Protein ID WP_025527253.1
Coordinates 2084533..2084835 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag CFH89_RS10595 Protein ID WP_005448240.1
Coordinates 2084823..2085080 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFH89_RS10525 2079680..2079736 - 57 WP_114867976.1 DUF3265 domain-containing protein -
CFH89_RS10530 2079865..2080158 + 294 WP_162814187.1 hypothetical protein -
CFH89_RS10540 2080399..2080983 - 585 WP_201452316.1 cold shock and DUF1294 domain-containing protein -
CFH89_RS10545 2081027..2081119 - 93 WP_008081753.1 DUF3265 domain-containing protein -
CFH89_RS10550 2081140..2081727 - 588 WP_114867662.1 hypothetical protein -
CFH89_RS10555 2081887..2082237 - 351 WP_042762920.1 RidA family protein -
CFH89_RS10560 2082386..2082682 - 297 WP_114867663.1 hypothetical protein -
CFH89_RS10565 2082848..2083252 - 405 WP_021705403.1 DUF1801 domain-containing protein -
CFH89_RS10570 2083407..2083928 - 522 WP_114867664.1 GNAT family N-acetyltransferase -
CFH89_RS10575 2083958..2084050 - 93 WP_140341327.1 DUF3265 domain-containing protein -
CFH89_RS10580 2084076..2084360 - 285 WP_103195693.1 nucleotide pyrophosphohydrolase -
CFH89_RS10585 2084405..2084497 - 93 WP_080285085.1 DUF3265 domain-containing protein -
CFH89_RS10590 2084533..2084835 - 303 WP_025527253.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFH89_RS10595 2084823..2085080 - 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CFH89_RS10600 2085162..2085251 - 90 WP_071652537.1 DUF3265 domain-containing protein -
CFH89_RS10605 2085772..2085876 - 105 WP_193234862.1 DUF3265 domain-containing protein -
CFH89_RS10610 2085879..2086496 - 618 WP_114867666.1 hypothetical protein -
CFH89_RS10615 2086519..2086641 - 123 WP_077281732.1 DUF3265 domain-containing protein -
CFH89_RS10620 2087079..2087630 - 552 WP_114867667.1 VRR-NUC domain-containing protein -
CFH89_RS10625 2087649..2087780 - 132 WP_114867668.1 DUF3265 domain-containing protein -
CFH89_RS10630 2088141..2088296 - 156 WP_079757872.1 DUF3265 domain-containing protein -
CFH89_RS10635 2088286..2088591 - 306 WP_025787418.1 hypothetical protein -
CFH89_RS10640 2088663..2088752 - 90 WP_072833118.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 2014345..2097853 83508


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11640.53 Da        Isoelectric Point: 4.8951

>T78727 WP_025527253.1 NZ_CP022243:c2084835-2084533 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLEAFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T78727 NZ_CP022243:c2084835-2084533 [Vibrio parahaemolyticus]
ATGGCTGAAATAATCTGGACTGAGCCAGCGCTATCCGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAACAATTGGTTCAAACGATCTTTTCTAAAGTCGAGCGCTTAGAGGCTTTCCCTGAATCGGGTCGCATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT78727 WP_005448240.1 NZ_CP022243:c2085080-2084823 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT78727 NZ_CP022243:c2085080-2084823 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACAAAGATCCTTGCCGATCTCCACGACACTAAAGAACCAGT
GTTAATTACCGAACATGGTAAGCCATCGGCATATCTGGTTGATGTTGATGATTACGAGTTTATGCAAAATCGTTTGGCGA
TTCTGGAGGGGATTGCACGAGGTGAACGTGCATTAGCTGACGGTAAAGTGGTGAGTCACGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2MSV0

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References