Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2489546..2490381 Replicon chromosome
Accession NZ_CP022229
Organism Escherichia coli strain WCHEC96200

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J1YPH7
Locus tag DBR04_RS13920 Protein ID WP_029701676.1
Coordinates 2489546..2489923 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0K5N986
Locus tag DBR04_RS13925 Protein ID WP_021553056.1
Coordinates 2490013..2490381 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBR04_RS13900 2485913..2487451 - 1539 WP_001187196.1 lysine decarboxylation/transport transcriptional activator CadC -
DBR04_RS13905 2488200..2489042 - 843 WP_022645115.1 DUF4942 domain-containing protein -
DBR04_RS26860 2489127..2489549 - 423 WP_001564064.1 DUF957 domain-containing protein -
DBR04_RS13920 2489546..2489923 - 378 WP_029701676.1 TA system toxin CbtA family protein Toxin
DBR04_RS13925 2490013..2490381 - 369 WP_021553056.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DBR04_RS13930 2490544..2490765 - 222 WP_000692345.1 DUF987 domain-containing protein -
DBR04_RS13935 2490830..2491306 - 477 WP_021553055.1 RadC family protein -
DBR04_RS13940 2491322..2491801 - 480 WP_001564060.1 antirestriction protein -
DBR04_RS13945 2492067..2492885 - 819 WP_001175165.1 DUF945 domain-containing protein -
DBR04_RS13950 2492975..2493208 - 234 WP_001278293.1 DUF905 family protein -
DBR04_RS13955 2493214..2493891 - 678 WP_001097302.1 hypothetical protein -
DBR04_RS13960 2494039..2494719 - 681 WP_029702103.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2478425..2524201 45776


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14066.04 Da        Isoelectric Point: 7.8045

>T78702 WP_029701676.1 NZ_CP022229:c2489923-2489546 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T78702 NZ_CP022229:c2489923-2489546 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13615.39 Da        Isoelectric Point: 7.0264

>AT78702 WP_021553056.1 NZ_CP022229:c2490381-2490013 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT78702 NZ_CP022229:c2490381-2490013 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1YPH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K5N986

References