78663

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1585886..1586442 Replicon chromosome
Accession NZ_CP022217
Organism Burkholderia thailandensis strain FDAARGOS_242

Toxin (Protein)


Gene name parE Uniprot ID A0A8A8D2I2
Locus tag A8H36_RS21120 Protein ID WP_034188048.1
Coordinates 1586152..1586442 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8A8D2B6
Locus tag A8H36_RS21115 Protein ID WP_025369732.1
Coordinates 1585886..1586164 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H36_RS32295 1581979..1582260 + 282 WP_144241897.1 hypothetical protein -
A8H36_RS21095 1582297..1583304 + 1008 WP_025369736.1 DUF4917 family protein -
A8H36_RS21100 1583369..1583629 - 261 WP_025369735.1 hypothetical protein -
A8H36_RS21105 1584143..1584460 + 318 WP_034188239.1 mobilization protein -
A8H36_RS21110 1584621..1585823 + 1203 WP_038712344.1 hypothetical protein -
A8H36_RS21115 1585886..1586164 + 279 WP_025369732.1 CopG family ribbon-helix-helix protein Antitoxin
A8H36_RS21120 1586152..1586442 + 291 WP_034188048.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8H36_RS21125 1586439..1586747 + 309 WP_061046262.1 hypothetical protein -
A8H36_RS21130 1586902..1587102 + 201 WP_025369730.1 hypothetical protein -
A8H36_RS21135 1587151..1587687 - 537 WP_051490136.1 hypothetical protein -
A8H36_RS21140 1587731..1588138 + 408 WP_009888727.1 transposase -
A8H36_RS21145 1588135..1588482 + 348 WP_009889515.1 IS66 family insertion sequence element accessory protein TnpB -
A8H36_RS21150 1588512..1590083 + 1572 WP_009889500.1 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10968.49 Da        Isoelectric Point: 9.5558

>T78663 WP_034188048.1 NZ_CP022217:1586152-1586442 [Burkholderia thailandensis]
MPQVIFAPAAIRDLQRLRDFLRPKNPDAARRAGEAIRQGVQALGTHPRMGRLVEDLPEHYREWPIDFGDSGYVARYRLDG
ETVTILAVRHQKEAGY

Download         Length: 291 bp

>T78663 NZ_CP022217:1586152-1586442 [Burkholderia thailandensis]
ATGCCGCAAGTGATCTTTGCGCCGGCGGCAATCCGAGACTTGCAACGGTTGCGCGACTTCCTGCGCCCGAAGAACCCTGA
CGCCGCGAGGCGGGCCGGCGAAGCAATTAGACAAGGCGTACAGGCTCTCGGCACCCACCCTCGAATGGGGCGTCTTGTAG
AAGACCTACCCGAGCATTATCGGGAGTGGCCCATCGATTTCGGGGATAGTGGTTACGTGGCCCGGTACCGCCTCGATGGC
GAAACCGTTACGATCTTGGCCGTCCGACATCAGAAGGAAGCGGGGTATTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10820.15 Da        Isoelectric Point: 5.2484

>AT78663 WP_025369732.1 NZ_CP022217:1585886-1586164 [Burkholderia thailandensis]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKRETLNKDTLKAWDEFQATGLHATAEEVDKWLASWG
TENELPTPECRK

Download         Length: 279 bp

>AT78663 NZ_CP022217:1585886-1586164 [Burkholderia thailandensis]
ATGGTAACAGCGACATCTATCAAGCTCGATGACGAACTGAAAGGGCGAGTACAGCACTTGGCTGAAGCGCGTCGGCGAAC
CCCGCACTGGATCATGCGCGAAGCCATCGAGCAGTACGTCGAGCGCGAGGAAAAGCGGGAGACGTTGAACAAGGACACGC
TCAAGGCGTGGGATGAGTTTCAGGCGACTGGTCTACACGCGACCGCTGAAGAAGTGGATAAGTGGCTCGCGAGCTGGGGA
ACTGAAAACGAGCTGCCCACGCCCGAATGCCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8A8D2I2

Antitoxin

Source ID Structure
AlphaFold DB A0A8A8D2B6

References