78662

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1589203..1589842 Replicon chromosome
Accession NZ_CP022216
Organism Burkholderia thailandensis strain FDAARGOS_242

Toxin (Protein)


Gene name hicA Uniprot ID Q2T3Q6
Locus tag A8H36_RS06880 Protein ID WP_009893919.1
Coordinates 1589663..1589842 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q2T3Q7
Locus tag A8H36_RS06875 Protein ID WP_011401461.1
Coordinates 1589203..1589619 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H36_RS06855 1586299..1587033 + 735 WP_009893914.1 hypothetical protein -
A8H36_RS06860 1587086..1587658 + 573 WP_009893915.1 site-specific integrase -
A8H36_RS06865 1588277..1588774 + 498 WP_011401460.1 hypothetical protein -
A8H36_RS06875 1589203..1589619 - 417 WP_011401461.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A8H36_RS06880 1589663..1589842 - 180 WP_009893919.1 type II toxin-antitoxin system HicA family toxin Toxin
A8H36_RS06885 1590122..1590649 + 528 WP_011401462.1 PAAR domain-containing protein -
A8H36_RS06890 1590646..1591380 + 735 WP_011401463.1 VRR-NUC domain-containing protein -
A8H36_RS06895 1591390..1592505 + 1116 WP_009893924.1 DUF3396 domain-containing protein -
A8H36_RS06900 1592576..1593151 - 576 WP_009893925.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - ddhA 1533244..1616164 82920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6618.82 Da        Isoelectric Point: 11.2336

>T78662 WP_009893919.1 NZ_CP022216:c1589842-1589663 [Burkholderia thailandensis]
MNSSKLIRMLEEDGWRLVRVTGSHHHFKHPKKPGLVTVPHPKKDLPIGTVKSIQKSAGL

Download         Length: 180 bp

>T78662 NZ_CP022216:c1589842-1589663 [Burkholderia thailandensis]
ATGAACTCATCGAAGCTGATCCGGATGCTTGAGGAAGATGGCTGGAGGTTGGTTCGAGTGACAGGCAGCCATCATCATTT
CAAACACCCCAAGAAGCCAGGTCTTGTGACGGTTCCCCACCCGAAGAAGGACCTACCGATTGGGACTGTAAAAAGCATCC
AGAAATCCGCCGGCCTGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15106.03 Da        Isoelectric Point: 4.6944

>AT78662 WP_011401461.1 NZ_CP022216:c1589619-1589203 [Burkholderia thailandensis]
MEFPIAVHKDDGSVYGVTVPDIPGVHSWGETIDDAIKNTREAIVGHVETLIELGDDVEFTCSTVEELVAKPEYAGAVWAL
VSVDLSQLDSKPERINVSIPRFVLHKIDAYVASRHETRSGFLARAALEALNEGKVRHA

Download         Length: 417 bp

>AT78662 NZ_CP022216:c1589619-1589203 [Burkholderia thailandensis]
ATGGAATTTCCCATCGCAGTGCATAAGGACGATGGGAGCGTCTACGGCGTGACGGTCCCGGATATTCCGGGCGTTCACTC
CTGGGGCGAAACCATCGATGATGCAATCAAAAACACGAGAGAGGCTATCGTCGGCCATGTAGAGACATTGATCGAGCTTG
GGGACGATGTTGAATTCACTTGCTCGACGGTGGAAGAACTGGTTGCAAAGCCCGAGTACGCCGGGGCGGTTTGGGCGCTC
GTCAGCGTTGATCTTTCTCAGCTTGATTCCAAGCCCGAGCGGATCAATGTGAGTATCCCTCGCTTCGTGCTGCACAAGAT
TGACGCCTATGTGGCATCCCGCCACGAGACTAGAAGCGGATTTCTTGCGCGTGCTGCCCTGGAGGCACTTAATGAAGGCA
AAGTTAGGCACGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4C26
PDB 6G26

Antitoxin

Source ID Structure
AlphaFold DB Q2T3Q7

References