78659

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 636768..637407 Replicon chromosome
Accession NZ_CP022215
Organism Burkholderia thailandensis strain FDAARGOS_241

Toxin (Protein)


Gene name hicA Uniprot ID Q2T3Q6
Locus tag A8H35_RS21970 Protein ID WP_009893919.1
Coordinates 637228..637407 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q2T3Q7
Locus tag A8H35_RS21965 Protein ID WP_011401461.1
Coordinates 636768..637184 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H35_RS21945 633864..634598 + 735 WP_009893914.1 hypothetical protein -
A8H35_RS21950 634651..635223 + 573 WP_009893915.1 site-specific integrase -
A8H35_RS21955 635842..636339 + 498 WP_011401460.1 hypothetical protein -
A8H35_RS21965 636768..637184 - 417 WP_011401461.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A8H35_RS21970 637228..637407 - 180 WP_009893919.1 type II toxin-antitoxin system HicA family toxin Toxin
A8H35_RS21975 637687..638214 + 528 WP_011401462.1 PAAR domain-containing protein -
A8H35_RS21980 638211..638945 + 735 WP_011401463.1 VRR-NUC domain-containing protein -
A8H35_RS21985 638955..640070 + 1116 WP_009893924.1 DUF3396 domain-containing protein -
A8H35_RS21990 640141..640716 - 576 WP_009893925.1 recombinase family protein -
A8H35_RS21995 641038..642018 - 981 WP_043037760.1 DUF3644 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 636768..656338 19570


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6618.82 Da        Isoelectric Point: 11.2336

>T78659 WP_009893919.1 NZ_CP022215:c637407-637228 [Burkholderia thailandensis]
MNSSKLIRMLEEDGWRLVRVTGSHHHFKHPKKPGLVTVPHPKKDLPIGTVKSIQKSAGL

Download         Length: 180 bp

>T78659 NZ_CP022215:c637407-637228 [Burkholderia thailandensis]
ATGAACTCATCGAAGCTGATCCGGATGCTTGAGGAAGATGGCTGGAGGTTGGTTCGAGTGACAGGCAGCCATCATCATTT
CAAACACCCCAAGAAGCCAGGTCTTGTGACGGTTCCCCACCCGAAGAAGGACCTACCGATTGGGACTGTAAAAAGCATCC
AGAAATCCGCCGGCCTGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15106.03 Da        Isoelectric Point: 4.6944

>AT78659 WP_011401461.1 NZ_CP022215:c637184-636768 [Burkholderia thailandensis]
MEFPIAVHKDDGSVYGVTVPDIPGVHSWGETIDDAIKNTREAIVGHVETLIELGDDVEFTCSTVEELVAKPEYAGAVWAL
VSVDLSQLDSKPERINVSIPRFVLHKIDAYVASRHETRSGFLARAALEALNEGKVRHA

Download         Length: 417 bp

>AT78659 NZ_CP022215:c637184-636768 [Burkholderia thailandensis]
ATGGAATTTCCCATCGCAGTGCATAAGGACGATGGGAGCGTCTACGGCGTGACGGTCCCGGATATTCCGGGCGTTCACTC
CTGGGGCGAAACCATCGATGATGCAATCAAAAACACGAGAGAGGCTATCGTCGGCCATGTAGAGACATTGATCGAGCTTG
GGGACGATGTTGAATTCACTTGCTCGACGGTGGAAGAACTGGTTGCAAAGCCCGAGTACGCCGGGGCGGTTTGGGCGCTC
GTCAGCGTTGATCTTTCTCAGCTTGATTCCAAGCCCGAGCGGATCAATGTGAGTATCCCTCGCTTCGTGCTGCACAAGAT
TGACGCCTATGTGGCATCCCGCCACGAGACTAGAAGCGGATTTCTTGCGCGTGCTGCCCTGGAGGCACTTAATGAAGGCA
AAGTTAGGCACGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4C26
PDB 6G26

Antitoxin

Source ID Structure
AlphaFold DB Q2T3Q7

References