78658

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1458098..1458654 Replicon chromosome
Accession NZ_CP022214
Organism Burkholderia thailandensis strain FDAARGOS_241

Toxin (Protein)


Gene name parE Uniprot ID A0A8A8D2I2
Locus tag A8H35_RS07375 Protein ID WP_034188048.1
Coordinates 1458098..1458388 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8A8D2B6
Locus tag A8H35_RS07380 Protein ID WP_025369732.1
Coordinates 1458376..1458654 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H35_RS07340 1453985..1454374 + 390 Protein_1331 hypothetical protein -
A8H35_RS07345 1454457..1456028 - 1572 WP_009889500.1 IS66 family transposase -
A8H35_RS07350 1456058..1456405 - 348 WP_009889515.1 IS66 family insertion sequence element accessory protein TnpB -
A8H35_RS07355 1456402..1456809 - 408 WP_009888727.1 transposase -
A8H35_RS07360 1456853..1457389 + 537 WP_051490136.1 hypothetical protein -
A8H35_RS07365 1457438..1457638 - 201 WP_025369730.1 hypothetical protein -
A8H35_RS07370 1457793..1458101 - 309 WP_061046262.1 hypothetical protein -
A8H35_RS07375 1458098..1458388 - 291 WP_034188048.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8H35_RS07380 1458376..1458654 - 279 WP_025369732.1 CopG family ribbon-helix-helix protein Antitoxin
A8H35_RS07385 1458717..1459919 - 1203 WP_038712344.1 hypothetical protein -
A8H35_RS07390 1460080..1460397 - 318 WP_034188239.1 mobilization protein -
A8H35_RS07395 1460911..1461171 + 261 WP_025369735.1 hypothetical protein -
A8H35_RS07400 1461236..1462243 - 1008 WP_025369736.1 DUF4917 family protein -
A8H35_RS32345 1462280..1462561 - 282 WP_144241897.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1449937..1470844 20907


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10968.49 Da        Isoelectric Point: 9.5558

>T78658 WP_034188048.1 NZ_CP022214:c1458388-1458098 [Burkholderia thailandensis]
MPQVIFAPAAIRDLQRLRDFLRPKNPDAARRAGEAIRQGVQALGTHPRMGRLVEDLPEHYREWPIDFGDSGYVARYRLDG
ETVTILAVRHQKEAGY

Download         Length: 291 bp

>T78658 NZ_CP022214:c1458388-1458098 [Burkholderia thailandensis]
ATGCCGCAAGTGATCTTTGCGCCGGCGGCAATCCGAGACTTGCAACGGTTGCGCGACTTCCTGCGCCCGAAGAACCCTGA
CGCCGCGAGGCGGGCCGGCGAAGCAATTAGACAAGGCGTACAGGCTCTCGGCACCCACCCTCGAATGGGGCGTCTTGTAG
AAGACCTACCCGAGCATTATCGGGAGTGGCCCATCGATTTCGGGGATAGTGGTTACGTGGCCCGGTACCGCCTCGATGGC
GAAACCGTTACGATCTTGGCCGTCCGACATCAGAAGGAAGCGGGGTATTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10820.15 Da        Isoelectric Point: 5.2484

>AT78658 WP_025369732.1 NZ_CP022214:c1458654-1458376 [Burkholderia thailandensis]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKRETLNKDTLKAWDEFQATGLHATAEEVDKWLASWG
TENELPTPECRK

Download         Length: 279 bp

>AT78658 NZ_CP022214:c1458654-1458376 [Burkholderia thailandensis]
ATGGTAACAGCGACATCTATCAAGCTCGATGACGAACTGAAAGGGCGAGTACAGCACTTGGCTGAAGCGCGTCGGCGAAC
CCCGCACTGGATCATGCGCGAAGCCATCGAGCAGTACGTCGAGCGCGAGGAAAAGCGGGAGACGTTGAACAAGGACACGC
TCAAGGCGTGGGATGAGTTTCAGGCGACTGGTCTACACGCGACCGCTGAAGAAGTGGATAAGTGGCTCGCGAGCTGGGGA
ACTGAAAACGAGCTGCCCACGCCCGAATGCCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8A8D2I2

Antitoxin

Source ID Structure
AlphaFold DB A0A8A8D2B6

References