Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1734379..1735656 Replicon chromosome
Accession NZ_CP022213
Organism Burkholderia gladioli pv. gladioli strain FDAARGOS_188

Toxin (Protein)


Gene name vapC Uniprot ID A0A808W951
Locus tag A8H28_RS25635 Protein ID WP_036049937.1
Coordinates 1735072..1735656 (+) Length 195 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A808W933
Locus tag A8H28_RS25630 Protein ID WP_036049935.1
Coordinates 1734379..1734969 (+) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H28_RS25610 1730979..1731416 + 438 WP_080742279.1 DUF4212 domain-containing protein -
A8H28_RS25615 1731410..1733425 + 2016 WP_036049934.1 VC_2705 family sodium/solute symporter -
A8H28_RS25620 1733469..1733892 + 424 Protein_1595 hypothetical protein -
A8H28_RS25625 1733959..1734222 + 264 WP_013698802.1 PAAR domain-containing protein -
A8H28_RS25630 1734379..1734969 + 591 WP_036049935.1 helix-turn-helix domain-containing protein Antitoxin
A8H28_RS25635 1735072..1735656 + 585 WP_036049937.1 HD domain-containing protein Toxin
A8H28_RS25645 1736224..1736961 + 738 WP_042286696.1 hypothetical protein -
A8H28_RS39930 1737366..1738184 + 819 WP_052710575.1 lytic transglycosylase domain-containing protein -
A8H28_RS25655 1738379..1739341 + 963 WP_036040951.1 AraC family transcriptional regulator -
A8H28_RS25660 1739466..1739882 - 417 WP_036053101.1 DUF302 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(8-187)

Antitoxin

Cro/C1-type helix-turn-helix domain

(27-73)


Sequences

Toxin        


Download         Length: 195 a.a.        Molecular weight: 21529.30 Da        Isoelectric Point: 5.0096

>T78656 WP_036049937.1 NZ_CP022213:1735072-1735656 [Burkholderia gladioli pv. gladioli]
MDDALIDARLDFLRGCERLKDVLRSGHTSGGRRESTAEHSWRLALMAMVLMDQLGEVDPGRVLELCLVHDLGEALGGDVP
APEQAPGSDKDAAERRDLLRLGDALDAPMRERIVALWDEYARAATPEARAVKALDKIETILQHTQGENPPDFDYAFNLAY
GQAHTRKVPALQRFRERVDEATRERMARAGGPSC

Download         Length: 585 bp

>T78656 NZ_CP022213:1735072-1735656 [Burkholderia gladioli pv. gladioli]
ATGGACGACGCGTTGATCGACGCACGACTGGATTTCCTGCGCGGCTGCGAGCGCCTGAAGGATGTGCTGCGCAGCGGCCA
TACCTCGGGCGGGCGACGCGAGAGCACGGCCGAGCACAGCTGGCGGCTCGCGCTGATGGCGATGGTGCTGATGGATCAAT
TGGGCGAGGTCGACCCCGGCAGGGTGCTCGAGCTCTGCCTGGTGCATGACCTGGGCGAAGCGCTGGGCGGCGACGTGCCG
GCGCCCGAGCAGGCCCCGGGCAGCGACAAGGATGCCGCCGAGCGACGCGACCTGCTGCGCCTCGGCGACGCGCTCGATGC
GCCGATGCGCGAGAGGATCGTCGCGTTGTGGGACGAGTATGCGCGGGCGGCCACGCCGGAAGCACGCGCGGTGAAGGCGC
TCGACAAGATCGAGACGATCCTGCAGCACACGCAGGGCGAGAATCCGCCCGATTTCGACTATGCGTTCAACCTCGCGTAT
GGACAGGCGCATACCCGCAAGGTGCCGGCGCTGCAGCGGTTTCGCGAGCGCGTCGACGAGGCGACGCGCGAGCGGATGGC
CCGTGCTGGCGGGCCTTCGTGCTGA

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 21473.34 Da        Isoelectric Point: 8.7063

>AT78656 WP_036049935.1 NZ_CP022213:1734379-1734969 [Burkholderia gladioli pv. gladioli]
MKPISSNQATTTSLPPSALACSPGASLRRWRTLRRIKQEHAAALFGVSQSTISRWEAGTQAVSHEELRRIEACLSARLDS
AADRALERLVSHHTRPVHLVCDLTHRLLACSAPRAAEFAAPLSSLMGASLWPFATAEIVAREQSLRDAGWQDHPAPSIEF
DTGSNDSPQVPIRASRCRWTRFTLSDGTLARLVETL

Download         Length: 591 bp

>AT78656 NZ_CP022213:1734379-1734969 [Burkholderia gladioli pv. gladioli]
ATGAAACCGATATCGTCGAACCAGGCAACGACCACGTCCTTGCCGCCGTCCGCGCTGGCCTGTTCGCCGGGCGCGAGCTT
GCGTCGATGGCGCACGCTGCGCCGGATCAAGCAGGAACATGCAGCGGCGCTGTTCGGCGTATCGCAGTCGACGATATCGC
GCTGGGAAGCCGGCACGCAGGCGGTGTCGCACGAGGAACTGCGGCGCATCGAGGCCTGCTTGTCGGCGCGCCTCGACTCG
GCGGCGGATCGCGCGCTCGAGCGCCTCGTCAGCCATCACACCCGTCCCGTTCATCTCGTCTGCGACCTCACGCACCGGCT
GCTGGCCTGCTCCGCGCCGCGAGCCGCGGAGTTCGCGGCGCCGCTGTCGTCGCTGATGGGCGCGTCGCTCTGGCCGTTCG
CGACGGCCGAGATCGTGGCGCGCGAGCAGTCGTTGCGCGATGCGGGCTGGCAAGATCATCCGGCACCCTCGATCGAATTC
GATACCGGGTCCAACGATTCGCCTCAGGTGCCGATTCGTGCGAGCCGCTGCCGCTGGACGCGTTTCACCTTGTCCGACGG
GACGCTGGCGCGCCTGGTCGAGACGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808W951

Antitoxin

Source ID Structure
AlphaFold DB A0A808W933

References