Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 24852..25444 Replicon plasmid unnamed3
Accession NZ_CP022212
Organism Burkholderia gladioli pv. gladioli strain FDAARGOS_188

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag A8H28_RS17230 Protein ID WP_036057804.1
Coordinates 24852..25145 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag A8H28_RS17235 Protein ID WP_080752326.1
Coordinates 25148..25444 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H28_RS17210 21057..21329 - 273 WP_080752327.1 transcriptional regulator -
A8H28_RS17215 21707..21919 - 213 WP_036057807.1 DUF3717 domain-containing protein -
A8H28_RS17220 22177..22533 - 357 WP_045577423.1 antirestriction protein -
A8H28_RS17225 22747..24777 + 2031 WP_158380916.1 ParB/Srx family N-terminal domain-containing protein -
A8H28_RS17230 24852..25145 + 294 WP_036057804.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8H28_RS17235 25148..25444 + 297 WP_080752326.1 putative addiction module antidote protein Antitoxin
A8H28_RS17240 25441..25701 - 261 WP_036057801.1 hypothetical protein -
A8H28_RS17245 25698..26096 - 399 WP_052710550.1 hypothetical protein -
A8H28_RS17250 26204..26683 - 480 WP_052710549.1 conjugal transfer protein TraD -
A8H28_RS17255 26691..27512 - 822 WP_144417599.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..63719 63719


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10865.36 Da        Isoelectric Point: 9.6552

>T78655 WP_036057804.1 NZ_CP022212:24852-25145 [Burkholderia gladioli pv. gladioli]
MVIEQTDDFAKWLRGLRDHIARAQIAKRIQRLAHGQYGDVKSVGAGVSELRVHTGPGYRVYFAQRGSTIIVLLCGGDKST
QQRDIQRAWALASELEE

Download         Length: 294 bp

>T78655 NZ_CP022212:24852-25145 [Burkholderia gladioli pv. gladioli]
ATGGTAATCGAACAGACAGACGATTTTGCGAAGTGGCTGCGCGGATTGCGCGACCACATCGCGCGTGCGCAAATCGCCAA
ACGGATTCAACGACTCGCCCACGGGCAGTATGGCGATGTCAAGTCGGTCGGCGCTGGTGTTAGCGAGTTACGGGTTCATA
CAGGGCCAGGATACAGGGTGTATTTCGCGCAGCGTGGTTCCACGATCATTGTGCTGCTGTGCGGCGGCGATAAATCCACT
CAGCAAAGAGATATTCAACGAGCATGGGCGCTTGCGTCCGAATTGGAGGAATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10500.76 Da        Isoelectric Point: 4.3867

>AT78655 WP_080752326.1 NZ_CP022212:25148-25444 [Burkholderia gladioli pv. gladioli]
MAIKTTPFDPADYLDSPEAQTEYLRESFESGDSADIQEAIGTVARARGMAQVALAAGVGRQSLYKALDERGNPEFATILS
VVRALGLNLTVTPTQRQA

Download         Length: 297 bp

>AT78655 NZ_CP022212:25148-25444 [Burkholderia gladioli pv. gladioli]
ATGGCAATCAAGACGACACCATTCGACCCAGCGGATTATCTCGACTCGCCCGAGGCGCAAACGGAATATCTCCGCGAGTC
GTTTGAATCCGGAGACTCGGCCGACATCCAAGAAGCGATCGGAACGGTTGCCCGAGCGCGGGGCATGGCTCAGGTCGCTC
TAGCGGCAGGCGTTGGCCGACAAAGCTTGTACAAGGCGCTGGACGAACGTGGCAATCCCGAGTTCGCAACGATCCTGAGC
GTTGTTCGAGCGCTCGGCCTCAACCTCACTGTCACGCCAACACAACGTCAAGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References