Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3884939..3886782 Replicon chromosome
Accession NZ_CP022210
Organism Burkholderia gladioli pv. gladioli strain FDAARGOS_188

Toxin (Protein)


Gene name doc Uniprot ID A0A808W4K9
Locus tag A8H28_RS16745 Protein ID WP_036057353.1
Coordinates 3885817..3886782 (-) Length 322 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag A8H28_RS16740 Protein ID WP_042285493.1
Coordinates 3884939..3885799 (-) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H28_RS16720 3880086..3881576 - 1491 WP_036056695.1 aldehyde dehydrogenase -
A8H28_RS16725 3881653..3882486 - 834 WP_036056696.1 aspartate dehydrogenase -
A8H28_RS16730 3882479..3884152 - 1674 WP_036056697.1 thiamine pyrophosphate-binding protein -
A8H28_RS16735 3884145..3884942 - 798 WP_013689909.1 SDR family oxidoreductase -
A8H28_RS16740 3884939..3885799 - 861 WP_042285493.1 IclR family transcriptional regulator Antitoxin
A8H28_RS16745 3885817..3886782 - 966 WP_036057353.1 alpha/beta fold hydrolase Toxin
A8H28_RS16750 3886809..3887336 - 528 WP_036038832.1 cupin domain-containing protein -
A8H28_RS16755 3887435..3888205 - 771 WP_036056699.1 SDR family oxidoreductase -
A8H28_RS16760 3888198..3889307 - 1110 WP_025097964.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
A8H28_RS16765 3889349..3889660 - 312 WP_025097963.1 hypothetical protein -
A8H28_RS16770 3889663..3889980 - 318 WP_013689902.1 non-heme iron oxygenase ferredoxin subunit -
A8H28_RS16775 3890395..3891474 + 1080 WP_017921239.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(66-304)

Antitoxin

Transcription regulator IclR, N-terminal

(25-73)


Sequences

Toxin        


Download         Length: 322 a.a.        Molecular weight: 32867.37 Da        Isoelectric Point: 7.3751

>T78653 WP_036057353.1 NZ_CP022210:c3886782-3885817 [Burkholderia gladioli pv. gladioli]
MSEIDPRGAEAEAGPDAALAARLWQFPARRIAIREAGLIGWRESGPAQGAGDSTARAAAGERALPVVLLHGIGSGAASWL
AQLDTLGASRRVLAWDAPGYGESTPVAPASPLAADYAASLAGWLDALAIERCVLVGHSLGAIVAGAFARRHAGRLAGLLL
VSPAAGYGAAPAATRDERRDARLAMLAALGPAGLAEQRSANMLSAHAGEAARAWVRRVMAQVKPAGYTQATHLLANADLA
ADLAAWRAMTDAAGAARVEVMVGAEDGITPPNACERIAAAAGVALRIVPRAGHAGYVEAPERYSALIGAFCARCDESWRQ
A

Download         Length: 966 bp

>T78653 NZ_CP022210:c3886782-3885817 [Burkholderia gladioli pv. gladioli]
ATGAGCGAAATCGATCCGCGCGGGGCCGAGGCAGAGGCTGGGCCCGACGCGGCCCTGGCCGCCCGACTCTGGCAGTTTCC
GGCGCGGCGCATCGCCATTCGCGAAGCCGGGCTGATCGGCTGGCGCGAATCGGGTCCAGCGCAGGGGGCCGGCGATTCGA
CGGCACGCGCGGCCGCTGGCGAGCGGGCATTGCCGGTGGTGCTGCTGCACGGCATCGGCTCGGGCGCGGCCTCGTGGCTG
GCCCAGCTCGACACGCTCGGCGCGTCGCGTCGCGTGCTGGCCTGGGACGCGCCCGGTTATGGCGAATCGACGCCGGTCGC
GCCGGCCTCGCCGCTGGCGGCCGATTACGCGGCGTCGCTGGCCGGCTGGCTCGACGCGCTCGCCATCGAGCGCTGCGTGC
TGGTGGGGCACTCGCTCGGCGCGATCGTGGCCGGCGCCTTCGCGCGCCGGCATGCCGGGCGGCTGGCCGGCTTGCTGCTG
GTTTCGCCGGCCGCCGGCTACGGCGCGGCACCGGCCGCCACGCGCGACGAACGGCGCGATGCGCGGCTCGCGATGCTGGC
CGCGCTCGGGCCCGCGGGCCTGGCCGAACAACGCAGCGCCAACATGCTGTCGGCGCATGCCGGCGAGGCCGCCCGCGCCT
GGGTGCGCCGCGTGATGGCGCAGGTGAAGCCGGCCGGCTACACGCAGGCCACCCACCTGCTCGCGAACGCCGACCTGGCC
GCCGATCTCGCCGCCTGGCGGGCGATGACCGACGCCGCCGGTGCCGCGCGCGTGGAGGTGATGGTGGGCGCCGAGGACGG
CATCACGCCGCCGAACGCCTGCGAACGGATCGCGGCGGCGGCCGGCGTGGCGCTGCGTATCGTGCCGCGCGCCGGCCATG
CCGGCTACGTGGAGGCACCCGAGCGCTACTCGGCGCTGATCGGCGCGTTCTGCGCGCGCTGCGACGAATCATGGAGACAG
GCATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31033.35 Da        Isoelectric Point: 6.5132

>AT78653 WP_042285493.1 NZ_CP022210:c3885799-3884939 [Burkholderia gladioli pv. gladioli]
MRSEPADSGAPEADAANGAYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNY
RLGVAVLRLGFEYLSSLELTDLGLPVIEGLREATGFTTHIVIRDGRDVVFVAKAQSAAPAFSSIRVNVGTRLPAHATTHG
HVLMGDLSEAELRALYPERQLERATRATPDSLEALLALVREDAARGYGISNASFERGISVVTAPVRNDTQRIVAAVTVTV
PKPEIDAALIADGLVEKVVRAANELSRRLNYRSDDENSYLKALGLR

Download         Length: 861 bp

>AT78653 NZ_CP022210:c3885799-3884939 [Burkholderia gladioli pv. gladioli]
CTGCGAAGCGAGCCGGCCGACAGCGGCGCGCCCGAGGCGGATGCCGCGAACGGCGCCTACGTGGTACCTGGCCTCGAACG
CGGGCTGCGGATCCTCGCGGAATTCTCGCCGCGCGAGCCGGTGCTGGGCGCGCCGGAATTGTCGAAGCGGCTCGGCATTC
CGCGCACCACGGTGTTCCGGCTGCTGCAGACGCTCGAATCGCTGGGCTTCCTGGAGCGCGCCGACAAGGACCGCAATTAC
CGGCTCGGCGTGGCGGTGCTGCGCCTGGGCTTCGAATACTTGAGCTCGCTGGAGCTGACCGACCTGGGCCTGCCGGTGAT
CGAGGGCCTGCGCGAGGCGACCGGCTTCACCACCCATATCGTGATCCGCGACGGGCGCGACGTGGTGTTCGTCGCCAAGG
CGCAGAGCGCGGCGCCGGCCTTCAGCTCGATTCGCGTCAACGTCGGCACGCGGCTGCCCGCGCATGCCACTACCCACGGC
CACGTGCTGATGGGCGACCTGAGCGAGGCCGAGCTGCGCGCACTGTACCCCGAGCGCCAGCTCGAACGGGCCACGCGTGC
CACGCCCGACAGCCTGGAGGCGCTGCTCGCGCTGGTCCGCGAGGATGCCGCGCGCGGCTACGGCATCAGCAACGCCTCGT
TCGAGCGCGGCATCTCGGTGGTCACCGCGCCGGTGCGCAACGACACGCAGCGCATCGTGGCGGCCGTCACGGTGACGGTG
CCGAAACCCGAGATCGACGCGGCGCTGATCGCCGACGGCCTGGTCGAGAAGGTCGTGAGGGCGGCCAATGAACTGTCGCG
GCGGCTCAATTACCGCTCCGATGATGAGAACTCCTATCTGAAGGCATTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808W4K9

Antitoxin

Source ID Structure

References