Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2739418..2740060 Replicon chromosome
Accession NZ_CP022210
Organism Burkholderia gladioli pv. gladioli strain FDAARGOS_188

Toxin (Protein)


Gene name vapC Uniprot ID A0A808W1S4
Locus tag A8H28_RS12180 Protein ID WP_036055816.1
Coordinates 2739638..2740060 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A808W4F3
Locus tag A8H28_RS12175 Protein ID WP_036033948.1
Coordinates 2739418..2739651 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H28_RS12160 2735386..2735634 - 249 WP_013690725.1 acyl carrier protein -
A8H28_RS12165 2735759..2737525 - 1767 WP_036055814.1 AMP-binding protein -
A8H28_RS12170 2738113..2739102 + 990 WP_036055815.1 LysR family transcriptional regulator -
A8H28_RS12175 2739418..2739651 + 234 WP_036033948.1 DNA-binding protein Antitoxin
A8H28_RS12180 2739638..2740060 + 423 WP_036055816.1 type II toxin-antitoxin system VapC family toxin Toxin
A8H28_RS12185 2740182..2740862 - 681 WP_036055817.1 deoxyribose-phosphate aldolase -
A8H28_RS12190 2741012..2741782 + 771 WP_036055818.1 DNA-binding transcriptional repressor DeoR -
A8H28_RS12195 2741802..2742884 - 1083 WP_036055819.1 aldose 1-epimerase family protein -
A8H28_RS12200 2742887..2744260 - 1374 WP_036055820.1 L-fucose:H+ symporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15659.95 Da        Isoelectric Point: 8.5438

>T78651 WP_036055816.1 NZ_CP022210:2739638-2740060 [Burkholderia gladioli pv. gladioli]
MYLIDTNVVSEVRKRDRADKGVMAFFRQAARDDAGLYLSVVTVGELRRGVEIIRHRGDESQATRLANWLDGVLREFAANI
LVVDKEIGQMWGYLRVPRPEHSLDKVIAATALIHDLTVVTRNVDDFAGTGARVLNPFKGP

Download         Length: 423 bp

>T78651 NZ_CP022210:2739638-2740060 [Burkholderia gladioli pv. gladioli]
ATGTATTTGATTGACACCAATGTGGTCAGCGAAGTCCGGAAACGGGATCGTGCGGACAAGGGTGTGATGGCCTTCTTTCG
CCAGGCGGCCCGCGACGATGCCGGCCTGTACCTGTCGGTGGTGACGGTGGGCGAACTGCGGCGAGGTGTGGAAATCATCC
GTCACCGTGGCGACGAATCCCAGGCAACGCGTCTCGCGAACTGGCTCGATGGCGTGCTCCGGGAGTTTGCCGCGAACATT
CTCGTGGTGGACAAGGAGATCGGGCAGATGTGGGGCTACCTGCGTGTACCTCGCCCGGAACACTCGCTGGATAAGGTGAT
CGCCGCCACGGCCTTGATTCACGATCTGACCGTGGTGACGCGCAACGTGGATGATTTCGCCGGAACCGGTGCCCGTGTGC
TGAACCCGTTCAAGGGCCCATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8484.61 Da        Isoelectric Point: 5.5741

>AT78651 WP_036033948.1 NZ_CP022210:2739418-2739651 [Burkholderia gladioli pv. gladioli]
MANLLVRNVDEMLVQILRERAAAHGHSAEAEHRAILARALREPQRKTFAQVLMGMPNVGSDADFARVDDGEAANVFD

Download         Length: 234 bp

>AT78651 NZ_CP022210:2739418-2739651 [Burkholderia gladioli pv. gladioli]
ATGGCGAATCTTCTGGTGAGAAACGTGGACGAAATGCTTGTTCAAATCTTGCGCGAGCGGGCTGCCGCTCACGGGCACAG
CGCGGAAGCCGAGCATCGTGCAATCCTGGCAAGGGCGCTGCGCGAGCCGCAACGCAAGACATTCGCGCAAGTGCTGATGG
GCATGCCGAACGTCGGTAGCGATGCCGATTTTGCGCGCGTGGACGATGGCGAGGCGGCGAATGTATTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808W1S4

Antitoxin

Source ID Structure
AlphaFold DB A0A808W4F3

References