Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2739418..2740060 Replicon chromosome
Accession NZ_CP022210
Organism Burkholderia gladioli pv. gladioli strain FDAARGOS_188

Toxin (Protein)


Gene name vapC Uniprot ID A0A808W1S4
Locus tag A8H28_RS12180 Protein ID WP_036055816.1
Coordinates 2739638..2740060 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A808W4F3
Locus tag A8H28_RS12175 Protein ID WP_036033948.1
Coordinates 2739418..2739651 (+) Length 78 a.a.

Genomic Context

A8H28_RS12170A8H28_RS12175A8H28_RS12180A8H28_RS12190A8H28_RS12160A8H28_RS12165A8H28_RS12185A8H28_RS12195A8H28_RS12200
Location: 2738113..2739102 (990 bp)
Type: Others
Protein ID: WP_036055815.1
Location: 2739418..2739651 (234 bp)
Type: Antitoxin
Protein ID: WP_036033948.1
Location: 2739638..2740060 (423 bp)
Type: Toxin
Protein ID: WP_036055816.1
Location: 2741012..2741782 (771 bp)
Type: Others
Protein ID: WP_036055818.1
Location: 2735386..2735634 (249 bp)
Type: Others
Protein ID: WP_013690725.1
Location: 2735759..2737525 (1767 bp)
Type: Others
Protein ID: WP_036055814.1
Location: 2740182..2740862 (681 bp)
Type: Others
Protein ID: WP_036055817.1
Location: 2741802..2742884 (1083 bp)
Type: Others
Protein ID: WP_036055819.1
Location: 2742887..2744260 (1374 bp)
Type: Others
Protein ID: WP_036055820.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A8H28_RS121602735386..2735634-249WP_013690725.1acyl carrier protein-
A8H28_RS121652735759..2737525-1767WP_036055814.1AMP-binding protein-
A8H28_RS121702738113..2739102+990WP_036055815.1LysR family transcriptional regulator-
A8H28_RS121752739418..2739651+234WP_036033948.1DNA-binding proteinAntitoxin
A8H28_RS121802739638..2740060+423WP_036055816.1type II toxin-antitoxin system VapC family toxinToxin
A8H28_RS121852740182..2740862-681WP_036055817.1deoxyribose-phosphate aldolase-
A8H28_RS121902741012..2741782+771WP_036055818.1DNA-binding transcriptional repressor DeoR-
A8H28_RS121952741802..2742884-1083WP_036055819.1aldose 1-epimerase family protein-
A8H28_RS122002742887..2744260-1374WP_036055820.1L-fucose:H+ symporter permease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15659.95 Da        Isoelectric Point: 8.5438

>T78651 WP_036055816.1 NZ_CP022210:2739638-2740060 [Burkholderia gladioli pv. gladioli]
MYLIDTNVVSEVRKRDRADKGVMAFFRQAARDDAGLYLSVVTVGELRRGVEIIRHRGDESQATRLANWLDGVLREFAANI
LVVDKEIGQMWGYLRVPRPEHSLDKVIAATALIHDLTVVTRNVDDFAGTGARVLNPFKGP

Download         Length: 423 bp

>T78651 NZ_CP022210:2739638-2740060 [Burkholderia gladioli pv. gladioli]
ATGTATTTGATTGACACCAATGTGGTCAGCGAAGTCCGGAAACGGGATCGTGCGGACAAGGGTGTGATGGCCTTCTTTCG
CCAGGCGGCCCGCGACGATGCCGGCCTGTACCTGTCGGTGGTGACGGTGGGCGAACTGCGGCGAGGTGTGGAAATCATCC
GTCACCGTGGCGACGAATCCCAGGCAACGCGTCTCGCGAACTGGCTCGATGGCGTGCTCCGGGAGTTTGCCGCGAACATT
CTCGTGGTGGACAAGGAGATCGGGCAGATGTGGGGCTACCTGCGTGTACCTCGCCCGGAACACTCGCTGGATAAGGTGAT
CGCCGCCACGGCCTTGATTCACGATCTGACCGTGGTGACGCGCAACGTGGATGATTTCGCCGGAACCGGTGCCCGTGTGC
TGAACCCGTTCAAGGGCCCATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8484.61 Da        Isoelectric Point: 5.5741

>AT78651 WP_036033948.1 NZ_CP022210:2739418-2739651 [Burkholderia gladioli pv. gladioli]
MANLLVRNVDEMLVQILRERAAAHGHSAEAEHRAILARALREPQRKTFAQVLMGMPNVGSDADFARVDDGEAANVFD

Download         Length: 234 bp

>AT78651 NZ_CP022210:2739418-2739651 [Burkholderia gladioli pv. gladioli]
ATGGCGAATCTTCTGGTGAGAAACGTGGACGAAATGCTTGTTCAAATCTTGCGCGAGCGGGCTGCCGCTCACGGGCACAG
CGCGGAAGCCGAGCATCGTGCAATCCTGGCAAGGGCGCTGCGCGAGCCGCAACGCAAGACATTCGCGCAAGTGCTGATGG
GCATGCCGAACGTCGGTAGCGATGCCGATTTTGCGCGCGTGGACGATGGCGAGGCGGCGAATGTATTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A808W1S4

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A808W4F3

References