Detailed information of TA system TA078650

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 847850..848425
• Replicon: chromosome
• Accession: NZ_CP022210
• Organism: Burkholderia gladioli pv. gladioli strain FDAARGOS_188

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: A8H28_RS04220
• Protein ID: WP_036054553.1
• Coordinates: 847850..848137 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A560UNM0
• Locus tag: A8H28_RS04225
• Protein ID: WP_036030606.1
• Coordinates: 848141..848425 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8H28_RS04200	843966..845027	-	1062	WP_013689307.1	selenide, water dikinase SelD	-
A8H28_RS04205	845272..846108	+	837	WP_036054549.1	DMT family transporter	-
A8H28_RS04210	846152..846622	-	471	WP_013689305.1	Lrp/AsnC family transcriptional regulator	-
A8H28_RS04215	846779..847717	+	939	WP_036054551.1	2-dehydropantoate 2-reductase	-
A8H28_RS04220	847850..848137	+	288	WP_036054553.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A8H28_RS04225	848141..848425	+	285	WP_036030606.1	putative addiction module antidote protein	Antitoxin
A8H28_RS04230	848483..848809	-	327	WP_036054555.1	hypothetical protein	-
A8H28_RS04235	848958..850085	-	1128	WP_167547494.1	ABC transporter substrate-binding protein	-
A8H28_RS04240	850271..851908	-	1638	WP_036054559.1	PLP-dependent aminotransferase family protein	-
A8H28_RS04245	852044..853327	+	1284	WP_013689299.1	4-aminobutyrate--2-oxoglutarate transaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (5-94)

Antitoxin

• Uncharacterized protein HI1420 (11-89)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10959.72 Da
• Isoelectric Point: 10.4966

>T78650 WP_036054553.1 NZ_CP022210:847850-848137 [Burkholderia gladioli pv. gladioli]
MLRSSEFTNWLSSLRDQRGKARIAARLISAQLGNFGEYRVIGEGVREMKVDFGPGYRIYYVRRAEIVYVLLCGGDKSTQK
KDIKRALQMARELKE

Nucleotide

• Length: 288 bp

>T78650 NZ_CP022210:847850-848137 [Burkholderia gladioli pv. gladioli]
TTGCTGCGCTCCAGTGAATTCACAAACTGGCTTTCCAGCCTGCGTGATCAGCGCGGCAAAGCCCGAATCGCCGCACGCCT
GATCAGTGCCCAGCTAGGCAATTTTGGCGAGTACCGCGTGATAGGCGAAGGCGTCCGCGAAATGAAGGTCGACTTCGGGC
CGGGTTATCGCATCTACTATGTCCGTCGCGCCGAGATCGTCTATGTCCTTCTCTGCGGTGGCGATAAATCTACACAGAAA
AAAGACATCAAGCGCGCGCTCCAGATGGCGCGCGAACTGAAGGAGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10072.47 Da
• Isoelectric Point: 5.0484

>AT78650 WP_036030606.1 NZ_CP022210:848141-848425 [Burkholderia gladioli pv. gladioli]
MPDYAEFDAADYLDNDETVAEFLAVAAEDPDPAVFLAAVAAVARARGMTKVASEAGLGRVTLHKALTPGAHPRYETVQKI
LRSLGLRMTFTVAH

Nucleotide

• Length: 285 bp

>AT78650 NZ_CP022210:848141-848425 [Burkholderia gladioli pv. gladioli]
ATGCCCGATTACGCCGAATTCGATGCGGCCGACTATCTCGACAATGACGAAACCGTGGCGGAATTTCTCGCGGTTGCGGC
AGAGGATCCCGATCCCGCAGTGTTCCTTGCTGCCGTGGCCGCTGTCGCACGCGCGCGCGGGATGACCAAGGTGGCGTCGG
AAGCCGGCCTTGGACGGGTCACCTTGCACAAGGCGCTGACGCCTGGCGCTCACCCTCGATATGAGACCGTGCAGAAGATC
CTGCGCTCGCTGGGCCTTCGCATGACCTTCACCGTCGCCCACTGA

Structures

Antitoxin

• AlphaFold DB: A0A560UNM0