Detailed information of TA system TA078649

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 3218242..3219194
• Replicon: chromosome
• Accession: NZ_CP022208
• Organism: Rhodococcus biphenylivorans strain TG9

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A0B1RG18
• Locus tag: CEJ39_RS15150
• Protein ID: WP_019289576.1
• Coordinates: 3218242..3218811 (-)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: CEJ39_RS15155
• Protein ID: WP_019289577.1
• Coordinates: 3218808..3219194 (-)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEJ39_RS15150	3218242..3218811	-	570	WP_019289576.1	zeta toxin family protein	Toxin
CEJ39_RS15155	3218808..3219194	-	387	WP_019289577.1	hypothetical protein	Antitoxin
CEJ39_RS15160	3219401..3220471	+	1071	WP_019289578.1	class I SAM-dependent methyltransferase	-
CEJ39_RS15165	3220541..3220906	+	366	WP_019289579.1	HNH endonuclease	-
CEJ39_RS15170	3220923..3221423	-	501	WP_162648041.1	hypothetical protein	-
CEJ39_RS15175	3222550..3223482	-	933	WP_019289581.1	TAXI family TRAP transporter solute-binding subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (7-67)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 20522.68 Da
• Isoelectric Point: 10.6895

>T78649 WP_019289576.1 NZ_CP022208:c3218811-3218242 [Rhodococcus biphenylivorans]
MRRLDLIVGPNGSGKSTFVELSLAPLLPRSVFVNADVIARQRWPDRAEEMSYEAAQLAAAARDRLLRQGRSFIAETVFSH
PSKLELIDRAHEVGFTVVLHVMLVPEAMSVLRVQHRVASGGHAVPEDKIRARYRRLWPLVAEAIGRADQASVYDTASGTP
VVVARFAGGVPVGAVRWPGWAPAALTGLG

Nucleotide

• Length: 570 bp

>T78649 NZ_CP022208:c3218811-3218242 [Rhodococcus biphenylivorans]
ATGAGGCGTCTGGATCTGATCGTCGGTCCCAACGGTTCCGGCAAGTCGACGTTCGTCGAGTTGTCCCTCGCTCCCCTGCT
GCCGCGCAGCGTGTTCGTCAATGCGGATGTGATCGCGCGGCAGCGCTGGCCCGACCGGGCGGAGGAGATGTCGTACGAGG
CGGCGCAGCTCGCCGCGGCGGCGCGGGACCGGTTGCTGCGGCAGGGCCGGTCGTTCATTGCGGAGACGGTGTTCTCGCAT
CCGTCGAAGCTGGAGTTGATCGACCGCGCGCACGAGGTGGGGTTCACGGTGGTGCTGCACGTGATGCTGGTGCCCGAGGC
GATGTCGGTGCTGCGTGTACAGCACCGGGTGGCCTCCGGTGGGCATGCGGTGCCCGAGGACAAGATCCGGGCGCGTTATC
GGCGGTTGTGGCCGCTGGTGGCCGAAGCGATCGGCCGCGCCGATCAGGCGTCGGTGTACGACACGGCGTCCGGGACCCCG
GTGGTGGTGGCGCGGTTCGCCGGCGGGGTGCCGGTGGGTGCGGTGCGCTGGCCGGGATGGGCGCCGGCGGCGCTCACCGG
GCTCGGCTGA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 13981.44 Da
• Isoelectric Point: 4.4910

>AT78649 WP_019289577.1 NZ_CP022208:c3219194-3218808 [Rhodococcus biphenylivorans]
MTSSTDKVTRFDAELVDSAIAEGGRQNRTGRQQLEYWARIGRAMTAHETASLHRVHEALAGTRELSELTAAEGRLFDAEI
DALLADGLARTDYAEILAARGVTTVVLDDEGRLVEQRPDGSRQVLDDA

Nucleotide

• Length: 387 bp

>AT78649 NZ_CP022208:c3219194-3218808 [Rhodococcus biphenylivorans]
ATGACGTCATCCACCGACAAGGTCACCCGCTTCGACGCCGAACTCGTCGACAGCGCCATCGCCGAGGGCGGCCGCCAGAA
CCGCACCGGACGCCAGCAACTCGAGTACTGGGCCCGCATCGGCCGCGCGATGACCGCCCACGAGACCGCCTCCCTGCACC
GGGTGCACGAGGCGCTGGCCGGGACACGGGAGCTGAGCGAGCTCACCGCCGCCGAGGGACGGCTGTTCGACGCGGAGATC
GATGCGCTCCTGGCGGACGGGCTGGCCCGCACCGACTACGCCGAGATTCTCGCCGCGCGTGGGGTCACCACGGTGGTGCT
CGACGACGAAGGCCGGCTGGTCGAGCAGCGTCCCGACGGTAGTCGCCAGGTGCTCGACGACGCATGA

Structures

Toxin

• AlphaFold DB: A0A0B1RG18