Detailed information of TA system TA078647

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1660363..1660975
• Replicon: chromosome
• Accession: NZ_CP022206
• Organism: Streptococcus pyogenes strain GURSA1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CFA72_RS08710
• Protein ID: WP_002994716.1
• Coordinates: 1660640..1660975 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: CFA72_RS08705
• Protein ID: WP_002988079.1
• Coordinates: 1660363..1660650 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFA72_RS08680	1655554..1656537	-	984	WP_093974863.1	tagatose-bisphosphate aldolase	-
CFA72_RS08685	1656541..1657470	-	930	WP_020837785.1	tagatose-6-phosphate kinase	-
CFA72_RS08690	1657516..1658031	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
CFA72_RS08695	1658066..1658494	-	429	WP_002991702.1	galactose-6-phosphate isomerase subunit LacA	-
CFA72_RS08700	1658940..1659713	+	774	WP_011285171.1	DeoR/GlpR family DNA-binding transcription regulator	-
CFA72_RS08705	1660363..1660650	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
CFA72_RS08710	1660640..1660975	+	336	WP_002994716.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CFA72_RS10085	1661127..1661597	+	471	WP_021733374.1	site-specific integrase	-
CFA72_RS10090	1661560..1662108	+	549	WP_136115776.1	site-specific integrase	-
CFA72_RS08720	1662228..1662620	-	393	WP_002982716.1	30S ribosomal protein S9	-
CFA72_RS08725	1662641..1663087	-	447	WP_002982710.1	50S ribosomal protein L13	-
CFA72_RS08730	1663305..1663511	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
CFA72_RS08735	1663508..1664014	-	507	WP_002988070.1	hypothetical protein	-
CFA72_RS08740	1664150..1665010	-	861	WP_002982687.1	DegV family protein	-
CFA72_RS08745	1665107..1665625	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13154.89 Da
• Isoelectric Point: 5.6157

>T78647 WP_002994716.1 NZ_CP022206:1660640-1660975 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T78647 NZ_CP022206:1660640-1660975 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT78647 WP_002988079.1 NZ_CP022206:1660363-1660650 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT78647 NZ_CP022206:1660363-1660650 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94