Detailed information of TA system TA078645

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 3095528..3096096
• Replicon: chromosome
• Accession: NZ_CP022188
• Organism: Azoarcus communis strain TSNA42

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CEW87_RS14100
• Protein ID: WP_108973941.1
• Coordinates: 3095725..3096096 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CEW87_RS14095
• Protein ID: WP_108973939.1
• Coordinates: 3095528..3095728 (+)
• Length: 67 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEW87_RS14090	3092846..3095464	+	2619	WP_108973937.1	BREX-1 system phosphatase PglZ type A	-
CEW87_RS14095	3095528..3095728	+	201	WP_108973939.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
CEW87_RS14100	3095725..3096096	+	372	WP_108973941.1	type II toxin-antitoxin system VapC family toxin	Toxin
CEW87_RS14105	3096096..3098129	+	2034	WP_108973943.1	protease Lon-related BREX system protein BrxL	-
CEW87_RS14110	3098224..3098721	-	498	WP_159098163.1	phage integrase SAM-like domain-containing protein	-
CEW87_RS22435	3098766..3098981	-	216	WP_159098164.1	hypothetical protein	-
CEW87_RS14120	3099423..3100676	+	1254	WP_108973947.1	HD domain-containing protein	-
CEW87_RS14125	3100684..3101049	-	366	WP_108973949.1	Hpt domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13463.59 Da
• Isoelectric Point: 5.5865

>T78645 WP_108973941.1 NZ_CP022188:3095725-3096096 [Azoarcus communis]
VILVDTSVWIDHLRKGEPVLVENLNAGTVLVHPFVIGEVGLGSLRQRELVLGALRDLPQAEVATDEEVSAFVEREHLFGL
GIGWVDAHLLAAVRLMPGVRLWSRDKRLAAVAARLGVATEWTN

Nucleotide

• Length: 372 bp

>T78645 NZ_CP022188:3095725-3096096 [Azoarcus communis]
GTGATTCTGGTCGACACGTCGGTGTGGATTGATCATCTGCGCAAGGGCGAGCCAGTACTGGTCGAGAACCTCAACGCGGG
GACGGTGCTGGTGCACCCCTTCGTGATTGGTGAGGTGGGTCTGGGCAGCTTGCGACAGCGCGAGCTTGTGCTGGGCGCGT
TGCGGGATCTACCACAGGCCGAAGTGGCGACGGACGAGGAGGTGAGTGCCTTTGTCGAGCGTGAGCATCTTTTTGGTCTT
GGGATAGGCTGGGTGGATGCGCATTTGCTGGCTGCCGTGCGCCTGATGCCGGGTGTGCGTTTGTGGTCGCGGGACAAGCG
GCTGGCTGCGGTGGCTGCGAGGCTTGGGGTGGCGACTGAATGGACAAATTGA

Antitoxin

Protein

• Length: 67 a.a.
• Molecular weight: 7267.29 Da
• Isoelectric Point: 5.0668

>AT78645 WP_108973939.1 NZ_CP022188:3095528-3095728 [Azoarcus communis]
MRTTIALDDALVERAQFFTGLTEKSALVREALKALIERESARRLALLGGSEPQLEDVSRRQAEPAA

Nucleotide

• Length: 201 bp

>AT78645 NZ_CP022188:3095528-3095728 [Azoarcus communis]
ATGCGTACAACCATTGCGCTTGATGACGCACTTGTCGAGCGCGCTCAGTTTTTCACTGGTCTGACCGAAAAGTCTGCGTT
GGTGCGTGAAGCGCTGAAGGCGCTGATAGAGCGTGAGAGCGCACGGCGACTGGCGCTGTTGGGGGGCTCGGAACCTCAGC
TGGAAGATGTATCGCGTCGTCAGGCGGAGCCAGCGGCGTGA