Detailed information of TA system TA078644

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2327130..2327815
• Replicon: chromosome
• Accession: NZ_CP022188
• Organism: Azoarcus communis strain TSNA42

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: -
• Locus tag: CEW87_RS10610
• Protein ID: WP_108972883.1
• Coordinates: 2327130..2327564 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: -
• Locus tag: CEW87_RS10615
• Protein ID: WP_108972884.1
• Coordinates: 2327561..2327815 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEW87_RS10580	2322188..2322880	-	693	WP_199917168.1	GNAT family N-acetyltransferase	-
CEW87_RS10585	2323041..2323289	+	249	WP_108972873.1	acyl carrier protein	-
CEW87_RS10590	2323303..2324508	-	1206	WP_108972875.1	pyridoxal-dependent decarboxylase, exosortase A system-associated	-
CEW87_RS10595	2324619..2324900	-	282	WP_108972877.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CEW87_RS10600	2324890..2325138	-	249	WP_108972879.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
CEW87_RS10605	2325217..2327025	-	1809	WP_108972881.1	asparagine synthase	-
CEW87_RS10610	2327130..2327564	-	435	WP_108972883.1	type II toxin-antitoxin system VapC family toxin	Toxin
CEW87_RS10615	2327561..2327815	-	255	WP_108972884.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CEW87_RS10620	2328006..2328305	-	300	WP_108972886.1	HEPN domain-containing protein	-
CEW87_RS10625	2328411..2328758	-	348	WP_108972888.1	nucleotidyltransferase domain-containing protein	-
CEW87_RS10630	2328870..2330450	-	1581	WP_108977125.1	acyl-CoA ligase (AMP-forming), exosortase A system-associated	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2304851..2335565	30714

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-127)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 16136.39 Da
• Isoelectric Point: 5.2906

>T78644 WP_108972883.1 NZ_CP022188:c2327564-2327130 [Azoarcus communis]
VKYMLDTNILIYLIKNKPPEVAERVDALNESDALCMSFVTFAELLKGAERSTRKQESLRKLEQLSREVPVQYETNRALSE
HYAIWFTALKAAGTPIGGNDLWIACHALAENATLVTNNTREFERIAGLRIENWAEPVAKSAAAD

Nucleotide

• Length: 435 bp

>T78644 NZ_CP022188:c2327564-2327130 [Azoarcus communis]
GTGAAGTACATGCTCGACACCAACATTCTGATCTACCTCATCAAGAACAAACCCCCGGAGGTAGCGGAGCGAGTCGACGC
ACTTAATGAGAGCGACGCCTTGTGCATGTCCTTTGTGACCTTCGCTGAGTTGCTCAAGGGCGCTGAACGCAGCACGCGCA
AGCAAGAATCCCTTCGCAAGCTCGAACAACTCAGTCGCGAGGTCCCCGTGCAATATGAAACGAATCGCGCCCTCTCCGAA
CACTACGCGATTTGGTTCACCGCGCTCAAGGCTGCAGGAACGCCGATCGGGGGCAACGACCTATGGATTGCGTGTCATGC
GCTCGCCGAGAATGCGACCCTGGTTACCAACAACACGCGTGAATTCGAACGTATCGCAGGCCTGCGGATCGAGAACTGGG
CCGAACCCGTAGCAAAATCGGCGGCGGCCGACTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9496.74 Da
• Isoelectric Point: 4.4550

>AT78644 WP_108972884.1 NZ_CP022188:c2327815-2327561 [Azoarcus communis]
MRTLISRVFTNGNSQAVRIPLELRLESRKVEITRTPNGDLLIHPIPSDRGQALLEALDGFDVDFIAALEADRNDQPEMQD
REPL

Nucleotide

• Length: 255 bp

>AT78644 NZ_CP022188:c2327815-2327561 [Azoarcus communis]
ATGCGCACCTTGATCAGCCGAGTTTTCACCAATGGCAACAGCCAAGCGGTCCGTATTCCACTGGAGCTACGCCTCGAGTC
GCGCAAAGTCGAGATCACGCGCACGCCTAACGGCGATCTGCTGATCCATCCAATCCCGTCGGATCGGGGTCAAGCCTTGC
TGGAAGCACTTGACGGCTTCGACGTCGACTTCATCGCCGCACTCGAAGCCGACCGCAACGATCAACCGGAGATGCAGGAC
AGGGAACCGCTGTGA