Detailed information of TA system TA078643

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2324619..2325138
• Replicon: chromosome
• Accession: NZ_CP022188
• Organism: Azoarcus communis strain TSNA42

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CEW87_RS10595
• Protein ID: WP_108972877.1
• Coordinates: 2324619..2324900 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CEW87_RS10600
• Protein ID: WP_108972879.1
• Coordinates: 2324890..2325138 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEW87_RS10570	2320205..2321176	-	972	WP_108972872.1	polysaccharide deacetylase family protein	-
CEW87_RS10575	2321462..2322109	+	648	WP_199917167.1	hypothetical protein	-
CEW87_RS10580	2322188..2322880	-	693	WP_199917168.1	GNAT family N-acetyltransferase	-
CEW87_RS10585	2323041..2323289	+	249	WP_108972873.1	acyl carrier protein	-
CEW87_RS10590	2323303..2324508	-	1206	WP_108972875.1	pyridoxal-dependent decarboxylase, exosortase A system-associated	-
CEW87_RS10595	2324619..2324900	-	282	WP_108972877.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CEW87_RS10600	2324890..2325138	-	249	WP_108972879.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CEW87_RS10605	2325217..2327025	-	1809	WP_108972881.1	asparagine synthase	-
CEW87_RS10610	2327130..2327564	-	435	WP_108972883.1	type II toxin-antitoxin system VapC family toxin	-
CEW87_RS10615	2327561..2327815	-	255	WP_108972884.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
CEW87_RS10620	2328006..2328305	-	300	WP_108972886.1	HEPN domain-containing protein	-
CEW87_RS10625	2328411..2328758	-	348	WP_108972888.1	nucleotidyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2304851..2335565	30714

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10861.59 Da
• Isoelectric Point: 10.4456

>T78643 WP_108972877.1 NZ_CP022188:c2324900-2324619 [Azoarcus communis]
MSYELSFKREALKEWQKLDATVREQFKSKLAERLDCPRVPSARLHGHPDRYKIKLRSAGYRLVYEVRDIEVVVVVVAVGK
RERDAVYRAAASR

Nucleotide

• Length: 282 bp

>T78643 NZ_CP022188:c2324900-2324619 [Azoarcus communis]
ATGAGCTATGAACTCAGCTTCAAGCGCGAAGCACTGAAAGAATGGCAAAAGCTCGATGCAACCGTCCGCGAACAGTTCAA
GAGCAAGCTGGCCGAGCGGCTTGATTGCCCACGAGTGCCCAGTGCTCGCTTGCATGGACACCCCGATCGCTACAAGATCA
AGCTACGTAGCGCCGGGTATCGGTTGGTGTACGAAGTACGCGACATCGAAGTCGTCGTGGTTGTTGTAGCCGTAGGCAAA
CGCGAGCGCGACGCAGTCTATCGGGCCGCGGCCTCCCGATAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8902.08 Da
• Isoelectric Point: 4.1220

>AT78643 WP_108972879.1 NZ_CP022188:c2325138-2324890 [Azoarcus communis]
MAHIILSQTTASISELKRNPMGTVAAGEGFPVAILNRNEPAFYCVPAATYEALLDRIEDLELNALADSRAAQDEIRVSLD
EL

Nucleotide

• Length: 249 bp

>AT78643 NZ_CP022188:c2325138-2324890 [Azoarcus communis]
ATGGCGCACATTATTCTGTCACAGACTACAGCAAGTATTTCTGAGCTAAAGCGCAACCCCATGGGTACCGTCGCGGCCGG
CGAAGGCTTTCCGGTCGCCATTCTCAACCGGAACGAGCCCGCCTTTTACTGCGTGCCGGCGGCAACCTACGAGGCCTTGC
TCGACCGCATCGAGGACCTCGAGCTGAACGCCCTTGCCGACAGCCGGGCCGCCCAGGATGAGATCAGGGTAAGCCTGGAT
GAGCTATGA