78642

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 350818..351860 Replicon chromosome
Accession NZ_CP022188
Organism Azoarcus communis strain TSNA42

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag CEW87_RS01585 Protein ID WP_003050248.1
Coordinates 350818..351393 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag CEW87_RS01590 Protein ID WP_003050245.1
Coordinates 351390..351860 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEW87_RS01560 347258..347983 - 726 WP_003050273.1 CBASS effector endonuclease NucC -
CEW87_RS01565 348020..348922 - 903 WP_003050264.1 nucleotidyltransferase domain-containing protein -
CEW87_RS01570 348922..349422 - 501 WP_003050262.1 hypothetical protein -
CEW87_RS01575 349419..349889 - 471 WP_003050260.1 hypothetical protein -
CEW87_RS01580 349886..350800 - 915 WP_003050256.1 AAA family ATPase -
CEW87_RS01585 350818..351393 - 576 WP_003050248.1 PIN domain-containing protein Toxin
CEW87_RS01590 351390..351860 - 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
CEW87_RS01595 352064..352447 + 384 WP_003050229.1 RAQPRD family integrative conjugative element protein -
CEW87_RS01600 352444..352677 + 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
CEW87_RS01605 352694..353053 + 360 WP_020307818.1 TIGR03745 family integrating conjugative element membrane protein -
CEW87_RS01610 353065..353463 + 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
CEW87_RS01615 353460..354152 + 693 WP_003050116.1 TIGR03746 family integrating conjugative element protein -
CEW87_RS01620 354149..355060 + 912 WP_003050114.1 TIGR03749 family integrating conjugative element protein -
CEW87_RS01625 355050..356468 + 1419 WP_003050111.1 TIGR03752 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21630.76 Da        Isoelectric Point: 5.6130

>T78642 WP_003050248.1 NZ_CP022188:c351393-350818 [Azoarcus communis]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

>T78642 NZ_CP022188:c351393-350818 [Azoarcus communis]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAACCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACAGGGCCATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTGCCCGATCCGGACGATCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGGGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTGCTGGATCTGGATGCGGCCGCCGTAGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGATGTGGACCGCTATCTCGAAATCCTGCTGCGCCAAGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT78642 WP_003050245.1 NZ_CP022188:c351860-351390 [Azoarcus communis]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp

>AT78642 NZ_CP022188:c351860-351390 [Azoarcus communis]
ATGACCACCGCCACTGCCCAATCCAAGATGACCCTTCCCGCCGCGGGAGAGGTTAAGGCAGCCGTCCAGGGTCAACGTGC
CTTGGCGGCTTACCTCGCAACCCAGTTCGAGACGCAGCACATCCAGATCTTTGATGACCACAAACAGGCTCATCAGGTGG
AACTGCCTACCTCGGCGTTGCGCCTGCTGGTCGACATCCTGGCCGAGTTGGCCGATGGCAATGCAGTAAAGGTGGTGCCC
GTCCATGCAGAGCTGACGACCCAAGAGGCGGCGGACTTGCTCAACGTGTCCCGTCCCCATTTCGTCAAGCTGCTAGAAGA
TGGGGTGTTGGCATTTCATCGCACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGATACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References