Detailed information of TA system TA078641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 3143413..3144463
• Replicon: chromosome
• Accession: NZ_CP022187
• Organism: Azoarcus communis strain TSPY31

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: CEW83_RS14260
• Protein ID: WP_108949933.1
• Coordinates: 3143882..3144463 (+)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: CEW83_RS14255
• Protein ID: WP_108949932.1
• Coordinates: 3143413..3143880 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEW83_RS14240	3139123..3140742	+	1620	WP_108949929.1	type I restriction-modification system subunit M	-
CEW83_RS14245	3141193..3142251	+	1059	WP_108949930.1	virulence RhuM family protein	-
CEW83_RS14250	3142248..3143195	+	948	WP_108949931.1	DUF91 domain-containing protein	-
CEW83_RS14255	3143413..3143880	+	468	WP_108949932.1	helix-turn-helix domain-containing protein	Antitoxin
CEW83_RS14260	3143882..3144463	+	582	WP_108949933.1	PIN domain-containing protein	Toxin
CEW83_RS14265	3144675..3145187	+	513	WP_108949934.1	inorganic diphosphatase	-
CEW83_RS14270	3145377..3146420	+	1044	WP_199915320.1	mechanosensitive ion channel	-
CEW83_RS14275	3146446..3147342	-	897	WP_108949936.1	LysR family transcriptional regulator	-
CEW83_RS14280	3147485..3148951	+	1467	WP_108949937.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-117)

Antitoxin

• Helix-turn-helix domain, group 17 (85-132)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21614.23 Da
• Isoelectric Point: 5.3069

>T78641 WP_108949933.1 NZ_CP022187:3143882-3144463 [Azoarcus communis]
MAGSARYTVILDACVLYPAPLRDVLLSLASAGLFHARWSERIQDEWVRNLLLQRPDLKLEDLQRTRTLMSSAIPDCLVTG
WEPIEQIITGLPDPNDRHVLAAALRGHADAIVTFNLKDFPAEVMDAVQVEIQHPDDFLLNQLDLAPFPALKAIKAMRARL
RKPPIEAAELVTMLEKLQLPLSAARLREVSELI

Nucleotide

• Length: 582 bp

>T78641 NZ_CP022187:3143882-3144463 [Azoarcus communis]
ATGGCAGGGTCGGCACGCTACACGGTGATTCTGGACGCTTGCGTGCTGTACCCAGCGCCTTTGCGCGACGTGCTCTTGAG
CCTTGCCAGTGCGGGGCTGTTCCATGCGCGCTGGTCTGAGCGGATTCAGGATGAGTGGGTTCGCAACCTCTTGCTGCAAC
GGCCGGATCTGAAGCTGGAGGATCTGCAGCGCACCCGTACATTGATGAGCAGTGCCATTCCAGATTGCCTCGTGACGGGG
TGGGAGCCCATCGAGCAGATCATTACGGGACTTCCAGACCCGAATGATCGTCATGTCCTTGCAGCCGCACTTCGCGGCCA
TGCCGACGCAATCGTGACATTCAATCTGAAAGACTTTCCGGCTGAAGTCATGGATGCGGTGCAGGTTGAGATTCAACACC
CAGACGATTTCCTGCTTAATCAACTCGATCTGGCGCCATTTCCGGCACTCAAAGCCATCAAGGCCATGCGTGCCAGACTG
CGCAAACCGCCCATTGAAGCAGCAGAACTGGTGACGATGCTTGAAAAACTTCAGCTTCCGCTAAGCGCGGCCAGACTGCG
TGAGGTCAGTGAGCTGATCTGA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17013.56 Da
• Isoelectric Point: 5.6374

>AT78641 WP_108949932.1 NZ_CP022187:3143413-3143880 [Azoarcus communis]
MANAQAAIDTVLDEHDAALAQAAQRCLMAALDHSRADTIRLIAKGEDQAEAVVELPPKVLRFMADLLGVMAQRQPVAVLP
QKLELSTQEVANMLNVSRPYVVKEIEAGHLPCRKVGRHRRVLFEDMIAYQQKSRSESDAALQALADQAQELGLGY

Nucleotide

• Length: 468 bp

>AT78641 NZ_CP022187:3143413-3143880 [Azoarcus communis]
ATGGCAAACGCGCAAGCAGCCATCGACACCGTGCTGGATGAGCACGATGCGGCACTGGCGCAAGCCGCTCAACGTTGCTT
GATGGCAGCGTTGGATCATTCGCGGGCGGACACCATACGGCTGATCGCAAAGGGTGAAGACCAGGCTGAGGCGGTCGTAG
AGCTACCCCCAAAGGTGTTGCGCTTCATGGCCGATCTGCTCGGGGTCATGGCACAGCGTCAGCCTGTAGCCGTGCTGCCG
CAGAAACTTGAACTCTCCACTCAGGAAGTGGCAAACATGCTGAATGTGTCGCGTCCGTACGTGGTCAAGGAGATCGAGGC
AGGACACCTGCCTTGCCGTAAGGTTGGTCGCCATCGGCGTGTCCTGTTCGAGGACATGATTGCTTATCAGCAGAAATCTC
GCTCTGAATCGGATGCGGCGTTGCAGGCCTTGGCCGATCAGGCTCAAGAGCTGGGCCTGGGGTACTGA