78640

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4166776..4167416 Replicon chromosome
Accession NZ_CP022186
Organism Aeromonas salmonicida strain S68

Toxin (Protein)


Gene name vagD Uniprot ID A0A807Z4U5
Locus tag CE462_RS20430 Protein ID WP_005320982.1
Coordinates 4167003..4167416 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A807Z5T0
Locus tag CE462_RS20425 Protein ID WP_005320985.1
Coordinates 4166776..4167006 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CE462_RS20405 4162752..4164143 + 1392 WP_034283822.1 T3SS effector protein-tyrosine-phosphatase AopH -
CE462_RS20410 4164216..4164617 - 402 Protein_3761 IS4 family transposase -
CE462_RS20415 4164685..4165602 + 918 WP_076611341.1 IS5-like element ISAs4 family transposase -
CE462_RS23590 4166019..4166408 + 390 WP_139403308.1 site-specific integrase -
CE462_RS20420 4166321..4166707 + 387 WP_017413139.1 tyrosine-type recombinase/integrase -
CE462_RS20425 4166776..4167006 + 231 WP_005320985.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CE462_RS20430 4167003..4167416 + 414 WP_005320982.1 PIN domain-containing protein Toxin
CE462_RS20435 4167494..4167847 + 354 WP_017413138.1 hypothetical protein -
CE462_RS20440 4167874..4168149 + 276 Protein_3768 hypothetical protein -
CE462_RS20445 4168207..4169124 - 918 WP_076611341.1 IS5-like element ISAs4 family transposase -
CE462_RS20450 4169359..4170276 - 918 WP_088814123.1 IS5-like element ISAs4 family transposase -
CE462_RS20455 4170463..4171044 - 582 Protein_3771 subclass B2 metallo-beta-lactamase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - aopH 4154803..4170276 15473
- inside IScluster/Tn - aopH 4154803..4172512 17709


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-42)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14935.23 Da        Isoelectric Point: 5.7146

>T78640 WP_005320982.1 NZ_CP022186:4167003-4167416 [Aeromonas salmonicida]
VKTFMLDTCICSFIMREMPQSVLERLGAEVASGNRIVISAITYAEMRYGQIGKKASPKLGPAIDEFVRRLDGILPWDAAT
VDQTLEVRQQLAALGTPIGNNDAAIAAHALTAGCVLVTNNTREFSRVAGLLYEDWVH

Download         Length: 414 bp

>T78640 NZ_CP022186:4167003-4167416 [Aeromonas salmonicida]
GTGAAGACGTTTATGCTCGATACCTGCATTTGTTCCTTCATCATGCGCGAAATGCCACAGTCAGTTCTTGAACGGTTGGG
CGCAGAGGTGGCGAGCGGCAATCGGATTGTGATCTCGGCAATCACCTACGCCGAAATGCGTTATGGCCAGATCGGCAAGA
AGGCTTCTCCGAAGCTGGGGCCAGCCATTGATGAATTTGTTCGTCGTCTCGATGGGATCTTGCCATGGGACGCTGCTACG
GTCGATCAGACGCTCGAAGTGCGCCAGCAGTTAGCAGCCTTGGGCACTCCGATCGGCAATAACGATGCTGCTATTGCCGC
CCACGCCCTGACGGCTGGCTGTGTACTGGTAACCAACAATACCCGCGAGTTTTCCCGAGTGGCGGGGCTGCTCTATGAAG
ACTGGGTTCACTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8699.88 Da        Isoelectric Point: 4.7419

>AT78640 WP_005320985.1 NZ_CP022186:4166776-4167006 [Aeromonas salmonicida]
MRTVSIFKNGKNQAVRLPKDMEFQGVNDLEIIKNGDTITLRPARPDWFSLAECQKVDADFLQERTDVISDEGRFAL

Download         Length: 231 bp

>AT78640 NZ_CP022186:4166776-4167006 [Aeromonas salmonicida]
ATGCGTACTGTATCAATTTTTAAAAATGGTAAAAATCAGGCGGTGAGACTGCCAAAAGACATGGAGTTTCAGGGGGTTAA
TGACCTTGAGATTATCAAAAATGGCGACACAATCACGTTGCGCCCGGCCCGCCCTGATTGGTTTTCCCTGGCGGAATGCC
AGAAGGTGGATGCAGATTTCTTGCAAGAACGTACCGATGTGATCAGCGATGAAGGACGGTTCGCCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807Z4U5

Antitoxin

Source ID Structure
AlphaFold DB A0A807Z5T0

References