Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 4166776..4167416 | Replicon | chromosome |
Accession | NZ_CP022186 | ||
Organism | Aeromonas salmonicida strain S68 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | A0A807Z4U5 |
Locus tag | CE462_RS20430 | Protein ID | WP_005320982.1 |
Coordinates | 4167003..4167416 (+) | Length | 138 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | A0A807Z5T0 |
Locus tag | CE462_RS20425 | Protein ID | WP_005320985.1 |
Coordinates | 4166776..4167006 (+) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CE462_RS20405 | 4162752..4164143 | + | 1392 | WP_034283822.1 | T3SS effector protein-tyrosine-phosphatase AopH | - |
CE462_RS20410 | 4164216..4164617 | - | 402 | Protein_3761 | IS4 family transposase | - |
CE462_RS20415 | 4164685..4165602 | + | 918 | WP_076611341.1 | IS5-like element ISAs4 family transposase | - |
CE462_RS23590 | 4166019..4166408 | + | 390 | WP_139403308.1 | site-specific integrase | - |
CE462_RS20420 | 4166321..4166707 | + | 387 | WP_017413139.1 | tyrosine-type recombinase/integrase | - |
CE462_RS20425 | 4166776..4167006 | + | 231 | WP_005320985.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
CE462_RS20430 | 4167003..4167416 | + | 414 | WP_005320982.1 | PIN domain-containing protein | Toxin |
CE462_RS20435 | 4167494..4167847 | + | 354 | WP_017413138.1 | hypothetical protein | - |
CE462_RS20440 | 4167874..4168149 | + | 276 | Protein_3768 | hypothetical protein | - |
CE462_RS20445 | 4168207..4169124 | - | 918 | WP_076611341.1 | IS5-like element ISAs4 family transposase | - |
CE462_RS20450 | 4169359..4170276 | - | 918 | WP_088814123.1 | IS5-like element ISAs4 family transposase | - |
CE462_RS20455 | 4170463..4171044 | - | 582 | Protein_3771 | subclass B2 metallo-beta-lactamase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | aopH | 4154803..4170276 | 15473 | |
- | inside | IScluster/Tn | - | aopH | 4154803..4172512 | 17709 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 14935.23 Da Isoelectric Point: 5.7146
>T78640 WP_005320982.1 NZ_CP022186:4167003-4167416 [Aeromonas salmonicida]
VKTFMLDTCICSFIMREMPQSVLERLGAEVASGNRIVISAITYAEMRYGQIGKKASPKLGPAIDEFVRRLDGILPWDAAT
VDQTLEVRQQLAALGTPIGNNDAAIAAHALTAGCVLVTNNTREFSRVAGLLYEDWVH
VKTFMLDTCICSFIMREMPQSVLERLGAEVASGNRIVISAITYAEMRYGQIGKKASPKLGPAIDEFVRRLDGILPWDAAT
VDQTLEVRQQLAALGTPIGNNDAAIAAHALTAGCVLVTNNTREFSRVAGLLYEDWVH
Download Length: 414 bp
>T78640 NZ_CP022186:4167003-4167416 [Aeromonas salmonicida]
GTGAAGACGTTTATGCTCGATACCTGCATTTGTTCCTTCATCATGCGCGAAATGCCACAGTCAGTTCTTGAACGGTTGGG
CGCAGAGGTGGCGAGCGGCAATCGGATTGTGATCTCGGCAATCACCTACGCCGAAATGCGTTATGGCCAGATCGGCAAGA
AGGCTTCTCCGAAGCTGGGGCCAGCCATTGATGAATTTGTTCGTCGTCTCGATGGGATCTTGCCATGGGACGCTGCTACG
GTCGATCAGACGCTCGAAGTGCGCCAGCAGTTAGCAGCCTTGGGCACTCCGATCGGCAATAACGATGCTGCTATTGCCGC
CCACGCCCTGACGGCTGGCTGTGTACTGGTAACCAACAATACCCGCGAGTTTTCCCGAGTGGCGGGGCTGCTCTATGAAG
ACTGGGTTCACTGA
GTGAAGACGTTTATGCTCGATACCTGCATTTGTTCCTTCATCATGCGCGAAATGCCACAGTCAGTTCTTGAACGGTTGGG
CGCAGAGGTGGCGAGCGGCAATCGGATTGTGATCTCGGCAATCACCTACGCCGAAATGCGTTATGGCCAGATCGGCAAGA
AGGCTTCTCCGAAGCTGGGGCCAGCCATTGATGAATTTGTTCGTCGTCTCGATGGGATCTTGCCATGGGACGCTGCTACG
GTCGATCAGACGCTCGAAGTGCGCCAGCAGTTAGCAGCCTTGGGCACTCCGATCGGCAATAACGATGCTGCTATTGCCGC
CCACGCCCTGACGGCTGGCTGTGTACTGGTAACCAACAATACCCGCGAGTTTTCCCGAGTGGCGGGGCTGCTCTATGAAG
ACTGGGTTCACTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8699.88 Da Isoelectric Point: 4.7419
>AT78640 WP_005320985.1 NZ_CP022186:4166776-4167006 [Aeromonas salmonicida]
MRTVSIFKNGKNQAVRLPKDMEFQGVNDLEIIKNGDTITLRPARPDWFSLAECQKVDADFLQERTDVISDEGRFAL
MRTVSIFKNGKNQAVRLPKDMEFQGVNDLEIIKNGDTITLRPARPDWFSLAECQKVDADFLQERTDVISDEGRFAL
Download Length: 231 bp
>AT78640 NZ_CP022186:4166776-4167006 [Aeromonas salmonicida]
ATGCGTACTGTATCAATTTTTAAAAATGGTAAAAATCAGGCGGTGAGACTGCCAAAAGACATGGAGTTTCAGGGGGTTAA
TGACCTTGAGATTATCAAAAATGGCGACACAATCACGTTGCGCCCGGCCCGCCCTGATTGGTTTTCCCTGGCGGAATGCC
AGAAGGTGGATGCAGATTTCTTGCAAGAACGTACCGATGTGATCAGCGATGAAGGACGGTTCGCCCTGTGA
ATGCGTACTGTATCAATTTTTAAAAATGGTAAAAATCAGGCGGTGAGACTGCCAAAAGACATGGAGTTTCAGGGGGTTAA
TGACCTTGAGATTATCAAAAATGGCGACACAATCACGTTGCGCCCGGCCCGCCCTGATTGGTTTTCCCTGGCGGAATGCC
AGAAGGTGGATGCAGATTTCTTGCAAGAACGTACCGATGTGATCAGCGATGAAGGACGGTTCGCCCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A807Z4U5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A807Z5T0 |